Integration of vestibular and gastrointestinal inputs by cerebellar fastigial nucleus neurons: multisensory influences on motion sickness.
Integration of vestibular and gastrointestinal inputs by cerebellar fastigial nucleus neurons: multisensory influences on motion sickness.
复制标题
DOI：
10.1007/s00221-014-3898-9
复制
发表时间：
2014-08
影响因子：
2
通讯作者：
Yates, Bill J.
中科院分区：
文献类型：
--
作者：
Catanzaro, Michael F.;Miller, Daniel J.;Cotter, Lucy A.;McCall, Andrew A.;Yates, Bill J.
先前的研究表明，摄入催吐化合物硫酸铜（CuSO4）改变了脑干区域中大部分神经元对前庭刺激的反应，这些神经元介导恶心和呕吐，从而影响运动病的易感性。其他研究表明，小脑神经元对前庭输入的处理在产生运动病中起着关键作用，小脑顶核中的神经元接受内脏输入。这些发现提出了这样的假设，即促肾上腺皮质激素化合物刺激胃肠道受体会影响顶核神经元对肾上腺素信号的处理。我们测试了这一假设，在去脑猫通过确定的影响，胃内注射硫酸铜对吻顶核的反应，全身旋转激活谷胱甘肽受体。前庭刺激小脑顶核神经元的反应更复杂的去大脑猫比以前报道的有意识的猫。特别是，时空收敛（STC）的反应，反映了不同的空间和时间属性的前庭输入的收敛，更常见于去大脑比有意识的猫。一小部分顶核神经元（15%）的放电率被改变超过50%的硫酸铜的管理，这些细胞的放电率下降。这些细胞中的大多数对前庭刺激的反应在提供化合物后减弱。虽然这些数据支持我们的假设，低分数的小脑顶核神经元的放电率和前庭刺激的反应受到硫酸铜的管理，怀疑的概念，即致晕内脏输入调制晕动病的易感性，主要是通过神经通路，包括小脑顶核。相反，似乎胃肠和前庭输入的会聚主要发生在脑干。
Previous studies demonstrated that ingestion of the emetic compound copper sulfate (CuSO4) alters the responses to vestibular stimulation of a large fraction of neurons in brainstem regions that mediate nausea and vomiting, thereby affecting motion sickness susceptibility. Other studies suggested that the processing of vestibular inputs by cerebellar neurons plays a critical role in generating motion sickness, and that neurons in the cerebellar fastigial nucleus receive visceral inputs. These findings raised the hypothesis that stimulation of gastrointestinal receptors by a nauseogenic compound affects the processing of labyrinthine signals by fastigial nucleus neurons. We tested this hypothesis in decerebrate cats by determining the effects of intragastric injection of CuSO4 on the responses of rostral fastigial nucleus to whole-body rotations that activate labyrinthine receptors. Responses to vestibular stimulation of fastigial nucleus neurons were more complex in decerebrate cats than reported previously in conscious felines. In particular, spatiotemporal convergence (STC) responses, which reflect the convergence of vestibular inputs with different spatial and temporal properties, were more common in decerebrate than in conscious felines. The firing rate of a small percentage of fastigial nucleus neurons (15%) was altered over 50% by the administration of CuSO4; the firing rate of the majority of these cells decreased. The responses to vestibular stimulation of a majority of these cells were attenuated after the compound was provided. Although these data support our hypothesis, the low fraction of fastigial nucleus neurons whose firing rate and responses to vestibular stimulation were affected by the administration of CuSO4 cast doubt on the notion that nauseogenic visceral inputs modulate motion sickness susceptibility principally through neural pathways that include the cerebellar fastigial nucleus. Instead, it appears that convergence of gastrointestinal and vestibular inputs occurs mainly in the brainstem.
登录
查看更多内容
影响因子：
2
作者：
Miller, D. M.;Cotter, L. A.;Yates, B. J.
通讯作者：
Yates, B. J.
影响因子：
2.5
作者：
Aleksandrov, VG;Bagaev, VA;Nozdrachev, AD
通讯作者：
Nozdrachev, AD
影响因子：
2.9
作者：
OKAHARA, K;NISIMARU, N
通讯作者：
NISIMARU, N
影响因子：
3.3
作者：
DeStefino, V. J.;Reighard, D. A.;Yates, B. J.
通讯作者：
Yates, B. J.
DOI：
10.1196/annals.1303.034
发表时间：
2003-01-01
期刊：
OCULOMOTOR AND VESTIBULAR SYSTEMS: THEIR FUNCTION AND DISORDERS
影响因子：
--
作者：
Cohen, B;Dai, MJ;Raphan, T
通讯作者：
Raphan, T