A case report of late-onset schizophrenia differentiated from a dementing disorder

A case report of late-onset schizophrenia differentiated from a dementing disorder
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与痴呆症相鉴别的迟发性精神分裂症一例报告

DOI:
10.1080/13554794.2021.2016858
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发表时间:
2021
期刊:
影响因子:
0.8
通讯作者:
Kawasaki Yasuhiro
Kawasaki Yasuhiro
中科院分区:
医学4区
文献类型:
--
作者:
Shimada Takamitsu;Uehara Takashi;Nagasawa Tatsuya;Hasegawa Mitsuru;Maeda Yoshiki;Kawasaki Yasuhiro

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我们报告一例迟发性精神分裂症,需要从痴呆症的分化。患者是一名83岁的女性,自67岁以来一直出现幻听。患者的总tau蛋白略微升高,淀粉样蛋白β1-42(脑脊液生物标志物)略微降低。该病例被确定为晚发性精神分裂症。然而,脑脊液生物标志物的结果表明,神经元缠结和神经元死亡,这是阿尔茨海默病的特征,也可能已经存在。迟发性精神分裂症应根据适当的鉴别诊断进行治疗,包括痴呆症的神经病理学考虑。
We report a case of late-onset schizophrenia that required differentiation from a dementing disorder. The patient was an 83-year-old woman who had experienced auditory hallucinations since she was 67 years old. The patient had slightly elevated total tau and slightly decreased amyloid β1-42, cerebrospinal fluid biomarkers. This case was identified as late-onset schizophrenia. However, the results of cerebrospinal fluid biomarkers indicated that neurofibrillary tangles and neuronal death, which are characteristic of Alzheimer ‘s disease, may also have been present. Late-onset schizophrenia should be treated based on an appropriate differential diagnosis, including neuropathological consideration of dementing disorders.
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