Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood.
Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood.
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DOI：
10.1038/mp.2010.53
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发表时间：
2011-07
影响因子：
11
通讯作者：
Cole, S. W.
中科院分区：
文献类型：
--
作者：
Chen, E.;Miller, G. E.;Kobor, M. S.;Cole, S. W.
从理论上讲，家庭支持可以缓冲处于逆境中的个人，使其免受不良后果的影响，这对心理和身体健康具有重要影响，但对解释这些联系的生物学机制知之甚少。我们假设，在低社会经济地位(SES)家庭长大但经历了高水平母性温暖的成年人将受到保护，免受通常与低SES相关的促炎状态的影响。对53名健康成人(年龄25-40岁)早期SES低的免疫激活和全身炎症标志物进行了评估。还进行了全基因组转录图谱分析。与那些母亲对他们表达高度温暖的早期生活自尊低的人相比，母亲对他们表达高温暖的低自尊个体表现出较少的Toll样受体刺激的白介素6的产生，以及促炎转录因子活性(NF-κB)和免疫激活转录因子活性(AP-1)的生物信息学指标降低。在某种程度上，这些影响是因果的，他们表明，早期低生活状态的SES环境的有害免疫影响可能会通过支持性的家庭氛围部分减弱。
The notion that family support may buffer individuals under adversity from poor outcomes has been theorized to have important implications for mental and physical health, but little is known about the biological mechanisms that explain these links. We hypothesized that adults who grew up in low socioeconomic status (SES) households but who experienced high levels of maternal warmth would be protected from the pro-inflammatory states typically associated with low SES. 53 healthy adults (ages 25–40) low in SES early in life were assessed on markers of immune activation and systemic inflammation. Genome-wide transcriptional profiling also was conducted. Low early life SES individuals who had mothers who expressed high warmth toward them exhibited less Toll-like receptor-stimulated production of interleukin 6, and reduced bioinformatic indications of pro-inflammatory transcription factor activity (NF-κB) and immune activating transcription factor activity (AP-1) compared to those who were low SES early in life but experienced low maternal warmth. To the extent that such effects are causal, they suggest the possibility that the detrimental immunologic effects of low early life SES environments may be partly diminished through supportive family climates.
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影响因子：
14.2
作者：
Chen, Edith;Hanson, Margaret D.;Miller, Gregory E.
通讯作者：
Miller, Gregory E.
影响因子：
5.8
作者：
Cole, SW;Yan, W;Zack, JA
通讯作者：
Zack, JA
影响因子：
6.6
作者：
HOUSE, JS;KESSLER, RC;HERZOG, AR
通讯作者：
HERZOG, AR
影响因子：
120.7
作者：
ADLER, NE;BOYCE, WT;SYME, SL
通讯作者：
SYME, SL
影响因子：
4
作者：
Evans, Gary W.;Kim, Pilyoung;Shannis, Dana
通讯作者：
Shannis, Dana