The expression of GLTSCR2 in cervical intra-epithelial lesion and cancer
The expression of GLTSCR2 in cervical intra-epithelial lesion and cancer
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GLTSCR2在宫颈上皮内病变及宫颈癌中的表达
DOI：
10.1007/s00404-014-3415-1
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Jiajing Chen
中科院分区：
文献类型：
--
作者：
Keli Sun;Bo Zhang;Qiu Jin;Jiajing Chen
背景GLTSCR 2最初被鉴定为几种类型癌症的候选肿瘤抑制因子。为探讨GLTSCR 2在不同宫颈病变组织中的表达情况，探讨其在宫颈癌发生中的作用，采用免疫组化方法对225例宫颈病变组织进行了研究。宫颈癌和高级别宫颈上皮内瘤变（CIN II-III）组织具有较低的GLTSCR 2的IHC染色表达评分。GLTSCR 2在CIN中的阳性染色信号随上皮内病变的分级而降低。宫颈癌组织中GLTSCR 2的免疫组化评分明显低于癌旁正常组织。与以往报道不同的是，我们还发现GLTSCR 2在宫颈组织的细胞核和细胞质中都有表达，并且几乎在所有组织中都观察到GLTSCR 2的细胞质表达。结论随着宫颈病变级别的升高，GLTSCR 2的表达逐渐降低。GLTSCR 2可能在宫颈癌的发生发展中起重要作用。
BackgroundGLTSCR2 was originally identified as a candidate tumor suppressor in several types of cancers. The present study was to investigate the expression pattern of GLTSCR2 in different cervical lesion tissues, appraise its potential role in cervical cancerogenesis.Methods225 histologically confirmed samples representing a wide range of cervical disease processes were studied in this study using immunohistochemistry (IHC).ResultsCompared with normal cervix and low-grade cervical intra-epithelial neoplasia (CIN I), cervical cancer and high-grade cervical intra-epithelial neoplasia (CIN II-III) tissues had lower expression scores of IHC staining of GLTSCR2. The positive staining signals of GLTSCR2 in CIN were decreased according to the grades of the intra-epithelial lesions. The IHC scores of GLTSCR2 in cervical cancer tissues were significantly lower than that in adjacent normal tissues. Different from previous report, we also found that GLTSCR2 was expressed in both nucleus and cytoplasm of cervical tissues, and the cytoplasmic expression of GLTSCR2 was observed in almost all tissues.ConclusionsWe demonstrated the GLTSCR2 expression decreased with the rise of the grade of cervical lesions. GLTSCR2 may play an important role in carcinogenesis of cervical cancer.
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影响因子：
9.7
作者：
Jee-Youn Kim;Young-Eun Cho;G. Kim;Hyung‐Lae Lee;Sun Lee;Jae-hoon Park
通讯作者：
Jee-Youn Kim;Young-Eun Cho;G. Kim;Hyung‐Lae Lee;Sun Lee;Jae-hoon Park
影响因子：
4.4
作者：
Smith, JS;Tachibana, I;Jenkins, RB
通讯作者：
Jenkins, RB
DOI：
10.1016/j.prp.2013.07.010
发表时间：
2013-11
期刊：
Pathology, research and practice
影响因子：
--
作者：
A. Moon;Sung‐Jig Lim;Young-Hwa Jo;Sun Lee;Jee-Youn Kim;Juhie Lee;Jae-hoon Park
通讯作者：
A. Moon;Sung‐Jig Lim;Young-Hwa Jo;Sun Lee;Jee-Youn Kim;Juhie Lee;Jae-hoon Park
影响因子：
9.7
作者：
Chung, TKH;Cheung, TH;Wong, YF
通讯作者：
Wong, YF
影响因子：
3.7
作者：
Kalt I;Levy A;Borodianskiy-Shteinberg T;Sarid R
通讯作者：
Sarid R