A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009).
A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009).
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DOI：
10.1016/j.phrs.2011.05.026
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发表时间：
2011-10
影响因子：
9.3
通讯作者：
Grayson, Dennis R.
中科院分区：
文献类型：
--
作者：
Guidotti, Alessandro;Grayson, Dennis R.
1996年，Costa博士应芝加哥伊利诺伊大学精神病学系主任Boris Astrachan教授的邀请，指导“芝加哥伊利诺伊大学医学院精神病学系精神病学研究所”的研究。他被要求开发一个关于精神疾病的开创性研究项目。回顾过去，科斯塔博士像往常一样迎接并超越了挑战。为了阐明养育（表观遗传因素）和自然（遗传因素）相互作用导致主要精神疾病的分子机制，科斯塔博士在精神病学研究所的最后15年研究的使命是中心。Costa博士和他的同事们（Auta、Caruncho、Davis、Grayson、Guidotti、Impagnatiello、Kiedrowski、Larson、Manev、Pappas、Pesold、Pinna、Sharma、Smalheiser、Sugaya、Tueting、Veldic [1-111]）面临的挑战一直是寻找新的方法来预防和治疗精神疾病，这些药物不会产生重大的不良副作用。在这个列表中，我们引用了与标题中突出显示的研究领域有关的论文的第一作者。Costa博士是一位兼收并蓄的科学家，在UIC的15年研究中，他触及了神经科学研究的许多其他方面，这些方面在本文中没有讨论。
In 1996, Dr. Costa was invited by Prof. Boris Astrachan, Chairman of the Department of Psychiatry at the University of Illinois at Chicago, to direct the research of the “Psychiatric Institute, Department of Psychiatry, School of Medicine, at the University of Illinois at Chicago.” He was asked to develop a seminal research program on psychiatric disorders. Viewed in retrospect, Dr. Costa met and surpassed the challenge, as was usual for him. To elucidate the molecular mechanisms whereby nurture (epigenetic factors) and nature (genetic factors) interact to cause major psychiatric disorders was at the center of Dr. Costa's mission for the last 15 years of his research at the Psychiatric Institute. The challenge for Dr. Costa and his colleagues (Auta, Caruncho, Davis, Grayson, Guidotti, Impagnatiello, Kiedrowski, Larson, Manev, Pappas, Pesold, Pinna, Sharma, Smalheiser, Sugaya, Tueting, Veldic [1–111]) had always been to find new ways to prevent and treat psychiatric disorders with pharmacological agents that failed to have major unwanted side effects. In this list, we have quoted the first authors of the papers pertaining to the field of research highlighted in the title. As you know, Dr. Costa was an eclectic scientist and in his 15 years of studies at UIC, he touched many other aspects of neuroscience research that are not discussed in this overview.
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DOI：
10.1615/critrevneurobiol.v15.i2.20
发表时间：
2003-01-01
期刊：
Critical Reviews in Neurobiology
影响因子：
--
作者：
Costa, Erminio;Grayson, Dennis R.;Guidotti, Alessandro
通讯作者：
Guidotti, Alessandro
影响因子：
1.7
作者：
Caruncho, HJ;Guidotti, A;Pesold, C
通讯作者：
Pesold, C
影响因子：
4.7
作者：
Auta, J;Costa, E;Guidotti, A
通讯作者：
Guidotti, A
影响因子：
--
作者：
Costa, E;Chen, Y;Guidotti, A
通讯作者：
Guidotti, A
DOI：
10.1615/critrevneurobiol.v16.i12.10
发表时间：
2004-01-01
期刊：
Critical Reviews in Neurobiology
影响因子：
--
作者：
Costa, E.;Davis, J. M.;Veldic, M.
通讯作者：
Veldic, M.