The human T-cell leukemia/lymphoma virus associated with American adult T-cell leukemia/lymphoma.
The human T-cell leukemia/lymphoma virus associated with American adult T-cell leukemia/lymphoma.
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与美国成人 T 细胞白血病/淋巴瘤相关的人类 T 细胞白血病/淋巴瘤病毒。
DOI：
10.1182/blood.v62.2.401.401
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发表时间：
1983
期刊：
影响因子：
20.3
通讯作者：
R. Gallo
中科院分区：
文献类型：
--
作者：
D. Blayney;E. Jaffe;W. Blattner;J. Cossman;M. Robert;D. Longo;P. Bunn;R. Gallo
The human T-cell leukemia/lymphoma virus (HTLV) is a novel type-C retrovirus isolated from patients with T-lymphoproliferative malignancies. Thirteen cases of HTLV-associated malignancy from US centers were studied in detail. Ten of these cases share common clinical features and define a typical virus-associated adult T-cell leukemia/lymphoma (ATL). All ten patients presented with Ann Arbor stage IV lymphoma because of skin involvement, bone marrow involvement, or lymphomatous leptomeningitis. Lymphadenopathy occurred in 7 of 10 patients at presentation, and the malignant cells were cytologically pleomorphic. Leukemia occurred in 60% of the patients at presentation. Hypercalcemia was found initially in two-thirds of the patients, with lytic bone lesions or positive bone scans in 7 of 10. Complete remission occurred in 40%, but all have relapsed. These cases closely resemble those virus-positive cases of adult T-cell leukemia/lymphoma (ATL) reported from Japan and the Caribbean. Three additional virus-positive patients had atypical presentations and diagnoses (acute lymphocytic leukemia, Sézary's syndrome, leukemic reticuloendotheliosis), usually with less aggressive clinical courses and atypical demographic and laboratory features. Presence of HTLV serum antibodies in cases of ATL (with hypercalcemia and circulating malignant cells) appears to define a distinct clinicopathologic entity that may occur in geographic clusters.
影响因子：
11.2
作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
通讯作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
一名患有成人 T 细胞白血病和皮肤淋巴瘤性血管炎的日本患者体内人类 T 细胞白血病病毒的鉴定。
DOI：
10.1073/pnas.80.7.2054
发表时间：
1983
影响因子：
11.1
作者：
Haynes,BF;Miller,SE;Palker,TJ;Moore,JO;Dunn,PH;Bolognesi,DP;Metzgar,RS
通讯作者：
Metzgar,RS
人 T 淋巴细胞衍生的粒细胞巨噬细胞集落刺激因子的纯化和表征。
影响因子：
20.3
作者：
Lusis,AJ;Quon,DH;Golde,DW
通讯作者：
Golde,DW