Signalling properties of inorganic polyphosphate in the mammalian brain.
Signalling properties of inorganic polyphosphate in the mammalian brain.
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DOI：
10.1038/ncomms2364
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
无机多磷酸盐已知以微摩尔浓度存在于哺乳动物大脑中。在这里，我们发现多磷酸盐可能作为胶质递质，介导星形胶质细胞之间的通讯。它以钙依赖的方式由星形胶质细胞释放，并通过P2Y1嘌呤能受体、磷脂酶C的激活和细胞内钙储存的释放向邻近星形胶质细胞发出信号。在原代神经胶质细胞培养中，当神经元吸收polyP时，应用polyP会触发星形胶质细胞释放内源性多磷酸盐。在体内，多磷酸盐在脑干水平上的中枢作用包括显著增加关键的体内平衡生理活动，如呼吸、中枢交感神经流出和动脉血压。总之，这些结果表明，在哺乳动物大脑中，多磷酸盐作为星形胶质细胞信号传递的介质的作用。在中枢神经系统中发现了无机多磷酸盐。Holmström和同事研究了体外神经胶质培养和体内心肺反应，发现无机多磷酸盐触发星形胶质细胞的钙依赖性激活并增加心肺活动。
Inorganic polyphosphate is known to be present in the mammalian brain at micromolar concentrations. Here we show that polyphosphate may act as a gliotransmitter, mediating communication between astrocytes. It is released by astrocytes in a calcium-dependent manner and signals to neighbouring astrocytes through P2Y1 purinergic receptors, activation of phospholipase C and release of calcium from the intracellular stores. In primary neuroglial cultures, application of polyP triggers release of endogenous polyphosphate from astrocytes while neurons take it up. In vivo, central actions of polyphosphate at the level of the brainstem include profound increases in key homeostatic physiological activities, such as breathing, central sympathetic outflow and the arterial blood pressure. Together, these results suggest a role for polyphosphate as a mediator of astroglial signal transmission in the mammalian brain. Inorganic polyphosphates have been identified in the central nervous system. Holmström and colleagues examine neuroglial cultures in vitro and cardiorespiratory responses in vivo, and find that inorganic polyphosphates trigger calcium-dependent activation of astrocytes and increase cardiorespiratory activity.
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DOI：
10.1523/jneurosci.3141-10.2010
发表时间：
2010-09-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Marina N;Abdala AP;Trapp S;Li A;Nattie EE;Hewinson J;Smith JC;Paton JF;Gourine AV
通讯作者：
Gourine AV
DOI：
10.1126/science.1190721
发表时间：
2010-07-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gourine AV;Kasymov V;Marina N;Tang F;Figueiredo MF;Lane S;Teschemacher AG;Spyer KM;Deisseroth K;Kasparov S
通讯作者：
Kasparov S
影响因子：
3.5
作者：
Bintig, Willem;Begandt, Daniela;Ngezahayo, Anaclet
通讯作者：
Ngezahayo, Anaclet
影响因子：
5.3
作者：
Kim, Donghee;Cavanaugh, Eric J.
通讯作者：
Cavanaugh, Eric J.
影响因子：
4.8
作者：
KUMBLE, KD;KORNBERG, A
通讯作者：
KORNBERG, A