Antibodies and Vaccines Target RBD of SARS-CoV-2.
Antibodies and Vaccines Target RBD of SARS-CoV-2.
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DOI：
10.3389/fmolb.2021.671633
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发表时间：
2021
影响因子：
5
通讯作者：
Sun Q
中科院分区：
文献类型：
--
作者：
Min L;Sun Q
引发2019年冠状病毒病(新冠肺炎)的新型人类冠状病毒--严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)对全球公共卫生造成严重威胁。2020年3月11日，世界卫生组织正式宣布新冠肺炎为大流行。因此，找到有效、安全的新冠肺炎中和抗体和疫苗至关重要。位于S蛋白(S蛋白)受体结合区的关键中和结构域可引起高效的中和抗体反应，并与其他SARS毒株产生交叉保护作用。通过使用RBD作为抗原，分离出了许多对新冠肺炎的治疗至关重要的中和抗体。此外，基于RBD的亚单位疫苗有望比其他亚单位疫苗更安全，因此S蛋白中的RBD是疫苗开发的更重要靶点。在这篇综述中，我们重点介绍了针对RBD的中和抗体以及目前正在开发的基于RBD的疫苗。
The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which gives rise to the coronavirus disease 2019 (COVID-19), has caused a serious threat to global public health. On March 11, 2020, the WHO had officially announced COVID-19 as a pandemic. Therefore, it is vital to find effective and safe neutralizing antibodies and vaccines for COVID-19. The critical neutralizing domain (CND) that is contained in the receptor-binding domain (RBD) of the spike protein (S protein) could lead to a highly potent neutralizing antibody response as well as the cross-protection of other strains of SARS. By using RBD as an antigen, many neutralizing antibodies are isolated that are essential to the therapeutics of COVID-19. Furthermore, a subunit vaccine, which is based on the RBD, is expected to be safer than others, thus the RBD in the S protein is a more important target for vaccine development. In this review, we focus on neutralizing antibodies that are targeting RBD as well as the vaccine based on RBD under current development.
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影响因子：
5.8
作者：
Du L;Yang Y;Zhou Y;Lu L;Li F;Jiang S
通讯作者：
Jiang S
影响因子：
56.9
作者：
Lv, Zhe;Deng, Yong-Qiang;Wang, Xiangxi
通讯作者：
Wang, Xiangxi
影响因子：
16.8
作者：
Huo, Jiangdong;Le Bas, Audrey;Naismith, James H.
通讯作者：
Naismith, James H.
影响因子：
39.3
作者：
Liu Z;Xu W;Xia S;Gu C;Wang X;Wang Q;Zhou J;Wu Y;Cai X;Qu D;Ying T;Xie Y;Lu L;Yuan Z;Jiang S
通讯作者：
Jiang S
REGN-COV2抗体预防和治疗恒河猕猴和仓鼠中的SARS-COV-2感染。
DOI：
10.1126/science.abe2402
发表时间：
2020-11-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Baum A;Ajithdoss D;Copin R;Zhou A;Lanza K;Negron N;Ni M;Wei Y;Mohammadi K;Musser B;Atwal GS;Oyejide A;Goez-Gazi Y;Dutton J;Clemmons E;Staples HM;Bartley C;Klaffke B;Alfson K;Gazi M;Gonzalez O;Dick E Jr;Carrion R Jr;Pessaint L;Porto M;Cook A;Brown R;Ali V;Greenhouse J;Taylor T;Andersen H;Lewis MG;Stahl N;Murphy AJ;Yancopoulos GD;Kyratsous CA
通讯作者：
Kyratsous CA