Infections and Atherosclerosis
Infections and Atherosclerosis
复制标题
感染和动脉粥样硬化
DOI：
--
复制
发表时间：
2000
影响因子：
2.2
通讯作者：
Maija Leinonen, Pekka Saikku
中科院分区：
文献类型：
--
作者：
Maija Leinonen, Pekka Saikku
世纪以前，炎症和感染被认为具有致动脉粥样硬化作用。然而，在上个世纪，这一假说被彻底抛弃，冠心病（CHD）可能有感染性病因的旧观点只是在最近几年才重新出现。病毒和细菌病原体都被认为与动脉粥样硬化中发现的炎症变化有关。疱疹组病毒，特别是巨细胞病毒（CMV）和单纯疱疹病毒1型（HSV 1），与动脉粥样硬化和再狭窄有关。幽门螺杆菌和牙齿感染也与冠心病有关，但呼吸道细菌肺炎衣原体的证据最强。这种关联最初是在血清流行病学研究中发现的，但动脉粥样硬化病变中存在微生物，第一次动物研究和初步成功的抗生素干预试验表明，C。pneumoniae可能在该病中起致病作用。因果关系尚未得到证实，但正在进行的大规模干预试验和发病机制的研究可能会导致在未来使用抗菌药物治疗CHD。
More than a century ago, inflammation and infection were considered to have atherogenic effects. During last century, however, this hypothesis was completely abandoned, and the old idea that coronary heart disease (CHD) possibly has an infectious etiology has only re-emerged in recent years. Both viral and bacterial pathogens have been proposed to be associated with the inflammatory changes found in atherosclerosis. Herpes group viruses, especially cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV1), have been associated with both atherosclerosis and restenosis. Helicobacter pylori and dental infections have also been linked to CHD, but the evidence is strongest for a respiratory tract bacterium, Chlamydia pneumoniae. The association was originally found in seroepidemiological studies, but the presence of organisms in atherosclerotic lesions, the first animal studies and preliminary successful intervention trials with antibiotics suggest that C. pneumoniae may have a pathogenetic role in the disease. The causal relationship has not yet been proven, but ongoing large intervention trials and research on pathogenetic mechanisms may lead to the use of antimicrobial agents in the treatment of CHD in the future.
登录
查看更多内容
DOI：
--
发表时间：
1983-05
期刊：
Federation proceedings
影响因子：
--
作者：
C. Fabricant;J. Fabricant;C. Minick;M. M. Litrenta-M.
通讯作者：
C. Fabricant;J. Fabricant;C. Minick;M. M. Litrenta-M.
影响因子：
6.4
作者：
Kalayoglu, MV;Byrne, GI
通讯作者：
Byrne, GI
影响因子：
15.9
作者：
Kol, A;Bourcier, T;Libby, P
通讯作者：
Libby, P
影响因子：
37.8
作者：
Kol, A;Sukhova, GK;Libby, P
通讯作者：
Libby, P
冠状动脉脂肪条纹和粥样斑块中肺炎衣原体的检测。
DOI：
--
发表时间：
1992
期刊：
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
影响因子：
--
作者：
Shor,A;Kuo,CC;Patton,DL
通讯作者：
Patton,DL