Overview of functional magnetic resonance imaging.

Overview of functional magnetic resonance imaging.
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DOI:
10.1016/j.nec.2010.11.001
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发表时间:
2011-04
影响因子:
2.6
通讯作者:
Glover, Gary H.
Glover, Gary H.
中科院分区:
医学3区
文献类型:
--
作者:
Glover, Gary H.

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血氧水平依赖性(BOLD)功能磁共振成像(fMRI)描述了任务诱导或自发调节神经代谢后脱氧血红蛋白浓度的变化。自1990年成立以来,该方法已被广泛用于数千项临床应用的认知研究,如手术计划,监测治疗结果,以及作为药理学和培训计划中的生物标志物。技术的发展已经解决了在实践中应用功能磁共振成像的大部分挑战。这些挑战包括BOLD信号的低对比度噪声比、图像失真和信号丢失。最近,注意力转向使用模式分类和其他统计方法,从功能磁共振成像数据中得出关于认知大脑状态的越来越复杂的推论。本文综述了功能磁共振成像的方法,一些挑战和未来。
Blood Oxygen Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) depicts changes in deoxyhemoglobin concentration consequent to task-induced or spontaneous modulation of neural metabolism. Since its inception in 1990, this method has been widely employed in thousands of studies of cognition for clinical applications such as surgical planning, for monitoring treatment outcomes, and as a biomarker in pharmacologic and training programs. Technical developments have solved most of the challenges of applying fMRI in practice. These challenges include low contrast to noise ratio of BOLD signals, image distortion, and signal dropout. More recently, attention is turning to the use of pattern classification and other statistical methods to draw increasingly complex inferences about cognitive brain states from fMRI data. This paper reviews the methods, some of the challenges and the future of fMRI.
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