Mycobacteriophages as Potential Therapeutic Agents against Drug-Resistant Tuberculosis.
Mycobacteriophages as Potential Therapeutic Agents against Drug-Resistant Tuberculosis.
复制标题
分枝杆菌噬菌体作为抗耐药结核病的潜在治疗剂。
DOI：
10.3390/ijms22020735
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发表时间：
2021-01-13
影响因子：
5.6
通讯作者：
Torrelles JB
中科院分区：
文献类型：
--
作者：
Allué-Guardia A;Saranathan R;Chan J;Torrelles JB
目前结核分枝杆菌的多重、广泛、极端和完全耐药菌株的出现构成了重大的健康、社会和经济威胁，并强调需要开发新的治疗策略。针对细菌的噬菌体疗法的概念已经存在了一个多世纪，尽管在引入药物后其实施被放弃，但它现在正在卷土重来，并在西方医学中重新获得作为治疗耐药病原体的替代方案的兴趣。分枝杆菌噬菌体是遗传多样性的病毒，其特异性地感染分枝杆菌宿主，包括分枝杆菌噬菌体的成员。肺结核综合征本文综述了分枝杆菌噬菌体的一般特征及其杀灭分枝杆菌的机制。结核分枝杆菌，以及它们的优点和局限性，作为治疗和预防药物对耐药M。结核菌株这篇综述还讨论了人肺微环境在塑造分枝杆菌噬菌体受体在M。结核病细胞包膜表面，细菌对分枝杆菌噬菌体的耐药性的潜在发展的风险，以及与哺乳动物宿主免疫系统的相互作用。最后，总结了知识的差距，并确定了关键问题要解决的噬菌体治疗耐药结核病的临床应用。
The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses the need to develop new therapeutic strategies. The notion of phage therapy against bacteria has been around for more than a century and, although its implementation was abandoned after the introduction of drugs, it is now making a comeback and gaining renewed interest in Western medicine as an alternative to treat drug-resistant pathogens. Mycobacteriophages are genetically diverse viruses that specifically infect mycobacterial hosts, including members of the M. tuberculosis complex. This review describes general features of mycobacteriophages and their mechanisms of killing M. tuberculosis, as well as their advantages and limitations as therapeutic and prophylactic agents against drug-resistant M. tuberculosis strains. This review also discusses the role of human lung micro-environments in shaping the availability of mycobacteriophage receptors on the M. tuberculosis cell envelope surface, the risk of potential development of bacterial resistance to mycobacteriophages, and the interactions with the mammalian host immune system. Finally, it summarizes the knowledge gaps and defines key questions to be addressed regarding the clinical application of phage therapy for the treatment of drug-resistant tuberculosis.
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影响因子：
5.6
作者：
Álvarez B;Biosca EG
通讯作者：
Biosca EG
DOI：
10.1073/pnas.1305923110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Barr, Jeremy J.;Auro, Rita;Rohwer, Forest
通讯作者：
Rohwer, Forest
影响因子：
5.2
作者：
Aziz RK;Dwivedi B;Akhter S;Breitbart M;Edwards RA
通讯作者：
Edwards RA
影响因子：
3.7
作者：
Carrigy, Nicholas B.;Chang, Rachel Y.;Vehring, Reinhard
通讯作者：
Vehring, Reinhard
DOI：
10.1080/21597081.2015.1020260
发表时间：
2015-01
期刊：
Bacteriophage
影响因子：
--
作者：
Abedon ST
通讯作者：
Abedon ST