Cumulative Incidence of SARS-CoV-2 Infections Among Adults in Georgia, United States, August to December 2020.
Cumulative Incidence of SARS-CoV-2 Infections Among Adults in Georgia, United States, August to December 2020.
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DOI：
10.1093/infdis/jiab522
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发表时间：
2022-02-01
期刊：
影响因子：
--
通讯作者：
Sullivan PS
中科院分区：
文献类型：
--
作者：
Chamberlain AT;Toomey KE;Bradley H;Hall EW;Fahimi M;Lopman BA;Luisi N;Sanchez T;Drenzek C;Shioda K;Siegler AJ;Sullivan PS
报告的2019冠状病毒病（COVID-19）病例低估了真正的严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）感染。需要关于所有感染者，包括无症状感染者的数据。为了最大限度地减少来自报告病例和血清阳性率调查的估计偏差，我们进行了以家庭为基础的概率调查，并估计了经抗体减弱调整的SARS-CoV-2感染的累积发病率。2020年8月至12月，我们向随机抽取的格鲁吉亚地址邮寄了标本采集包（鼻拭子和血斑）。一名家庭成年人完成了调查，并返回样本进行病毒和抗体检测。我们估计了SARS-CoV-2感染的累积发病率，调整了减弱的抗体、报告的分数和感染病死率（IFR）。采用加权患病率（PR）探讨了人口统计学、地理和临床亚组之间血清阳性率的差异。在1370名参与者中，截至2020年11月16日，调整后的SARS-CoV-2累积发病率为16.1%（95%可信区间[CrI]，13.5%-19.2%）。报告的分数为26.6%，IFR为0.78%。非西班牙裔黑人（PR，2.03; 95%置信区间[CI]，1.0-4.1）和西班牙裔成年人（PR，1.98; 95%CI，0.74 -5.31）比非西班牙裔白色成年人更有可能出现血清阳性。截至2020年11月中旬，格鲁吉亚每6名成年人中就有1人感染过SARS-CoV-2。格鲁吉亚的COVID-19疫情可能被报告的病例大大低估了。使用美国格鲁吉亚家庭概率调查的数据，我们估计，截至2020年11月16日，130万年龄≥18岁的成年人经历了SARS-CoV-2感染，其中四分之一被报告，其中0.78%死亡。
Reported coronavirus disease 2019 (COVID-19) cases underestimate true severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Data on all infections, including asymptomatic infections, are needed. To minimize biases in estimates from reported cases and seroprevalence surveys, we conducted a household-based probability survey and estimated cumulative incidence of SARS-CoV-2 infections adjusted for antibody waning. From August to December 2020, we mailed specimen collection kits (nasal swabs and blood spots) to a random sample of Georgia addresses. One household adult completed a survey and returned specimens for virus and antibody testing. We estimated cumulative incidence of SARS-CoV-2 infections adjusted for waning antibodies, reported fraction, and infection fatality ratio (IFR). Differences in seropositivity among demographic, geographic, and clinical subgroups were explored with weighted prevalence ratios (PR). Among 1370 participants, adjusted cumulative incidence of SARS-CoV-2 was 16.1% (95% credible interval [CrI], 13.5%–19.2%) as of 16 November 2020. The reported fraction was 26.6% and IFR was 0.78%. Non-Hispanic black (PR, 2.03; 95% confidence interval [CI], 1.0–4.1) and Hispanic adults (PR, 1.98; 95% CI, .74–5.31) were more likely than non-Hispanic white adults to be seropositive. As of mid-November 2020, 1 in 6 adults in Georgia had been infected with SARS-CoV-2. The COVID-19 epidemic in Georgia is likely substantially underestimated by reported cases. Using data from a probability survey of households in Georgia, United States we estimated that 1.3 million adults aged ≥18 years experienced SARS-CoV-2 infections by 16 November 2020, of whom 1 in 4 were reported and of whom 0.78% died.
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DOI：
10.1097/ede.0000000000001361
发表时间：
2021-07-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Shioda K;Lau MSY;Kraay ANM;Nelson KN;Siegler AJ;Sullivan PS;Collins MH;Weitz JS;Lopman BA
通讯作者：
Lopman BA
影响因子：
5.6
作者：
Lavange, Lisa M.;Kalsbeek, William D.;Sorlie, Paul D.;Aviles-Santa, Larissa M.;Kaplan, Robert C.;Barnhart, Janice;Liu, Kiang;Giachello, Aida;Lee, David J.;Ryan, John;Criqui, Michael H.;Elder, John P.
通讯作者：
Elder, John P.
影响因子：
8.5
作者：
Sullivan, Patrick Sean;Sailey, Charles;Sanchez, Travis Howard
通讯作者：
Sanchez, Travis Howard
影响因子：
5.6
作者：
Siegler, Aaron J.;Sullivan, Patrick S.;Bradley, Heather
通讯作者：
Bradley, Heather
DOI：
10.15585/mmwr.mm7010e3externalicon
发表时间：
2021-03-12
影响因子：
33.9
作者：
Guy, Gery P., Jr.;Lee, Florence C.;Massetti, Greta M.
通讯作者：
Massetti, Greta M.