Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation.
Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation.
复制标题
大黄素对预防术后腹腔粘连形成的作用。
DOI：
10.1155/2017/1740317
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发表时间：
2017
影响因子：
--
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Wei G;Wu Y;Gao Q;Zhou C;Wang K;Shen C;Wang G;Wang K;Sun X;Li X
术后腹腔粘连是腹部手术后的主要并发症。虽然各种方法已被用于预防和治疗粘连，但效果并不令人满意。大黄素是一种天然存在的蒽醌衍生物，也是传统中药的有效成分，具有多种药理作用。在我们的研究中，我们证明了大黄素治疗对预防术后粘连形成的作用。 将48只大鼠分为6组。盲肠及其对侧腹壁的磨损造成腹部粘连。在实验组中，大鼠每天口服大黄素。术后第7天处死大鼠，取血及病理标本。通过尸检、病理学、免疫组织化学、蛋白质印迹和酶联免疫吸附试验分析评价腹部粘连形成。 腹腔粘连明显减少大黄素治疗。与对照组相比，大黄素治疗组胶原沉积减少，腹膜间皮完整率较高。大黄素具有抗炎、减轻氧化应激、促进肠道运动的作用（P < 0.05）。 大黄素显着减少腹腔粘连形成的大鼠模型。
Postoperative intra-abdominal adhesions are a major complication after abdominal surgery. Although various methods have been used to prevent and treat adhesions, the effects have not been satisfactory. Emodin, a naturally occurring anthraquinone derivative and an active ingredient in traditional Chinese herbs, exhibits a variety of pharmacological effects. In our study, we demonstrated the effect of emodin treatment on preventing postoperative adhesion formation. A total of 48 rats were divided into six groups. Abdominal adhesions were created by abrasion of the cecum and its opposite abdominal wall. In the experimental groups, the rats were administered daily oral doses of emodin. On the seventh day after operation, the rats were euthanized, and blood and pathological specimens were collected. Abdominal adhesion formation was evaluated by necropsy, pathology, immunohistochemistry, Western blot, and enzyme-linked immunosorbent assay analyses. Abdominal adhesions were markedly reduced by emodin treatment. Compared with the control group, collagen deposition was reduced and the peritoneal mesothelial completeness rate was higher in the emodin-treated groups. Emodin had anti-inflammatory effects, reduced oxidative stress, and promoted the movement of the intestinal tract (P < 0.05). Emodin significantly reduced intra-abdominal adhesion formation in a rat model.
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影响因子：
6
作者：
Gorvy, DA;Herrick, SE;Ferguson, MWJ
通讯作者：
Ferguson, MWJ
影响因子：
3.2
作者：
Ersoy, Eren;Ozturk, Vedat;Gundogdu, Haldun
通讯作者：
Gundogdu, Haldun
影响因子：
2.2
作者：
Du, Ming-Hua;Luo, Hong-Min;Hu, Sen
通讯作者：
Hu, Sen
影响因子：
2.6
作者：
Gustafsson, U. O.;Scott, M. J.;Ljungqvist, O.
通讯作者：
Ljungqvist, O.
影响因子：
6.3
作者：
Gustafsson, U. O.;Scott, M. J.;Ljungqvist, O.
通讯作者：
Ljungqvist, O.