Quantitative assessment of TIM-3 polymorphisms and cancer risk in Chinese Han population.
Quantitative assessment of TIM-3 polymorphisms and cancer risk in Chinese Han population.
复制标题
中国汉族人群TIM-3多态性与癌症风险的定量评估
DOI：
10.18632/oncotarget.8157
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发表时间：
2016-06-14
期刊：
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Gao X;Yang J;He Y;Zhang J
以往的研究调查了TIM-3基因多态性（− 1516 G/T，− 574 G/T和+4259T/G）与中国汉族人群癌症风险的关系，但结果仍然存在争议。因此，我们进行了荟萃分析，以获得更精确的关联估计。汇总数据显示，TIM-3多态性（− 1516 G/T、− 574 G/T和+4259 T/G）与中国汉族人群总体癌症风险增加显著相关。基于癌症系统的亚组分析显示，TIM-3 − 1516 G/T多态性仅与中国汉族人群消化系统癌症风险增加相关。TIM-3 − 574 G/T多态性与中国汉族人群消化系统癌及其他癌症的风险增加相关。TIM-3 + 4259 T/G多态性仅与中国汉族人群其他癌症的风险增加相关。总之，我们的结果表明TIM-3多态性（− 1516 G/T，− 574 G/T和+4259 T/G）与中国汉族人群癌症风险增加相关。
Previous studies have investigated the associations of TIM-3 polymorphisms (−1516G/T, −574G/T, and +4259T/G) with cancer risk in Chinese Han population, but the results remain conflicting. Therefore, we conducted a meta-analysis to derive a more precise estimation of the associations. The pooled data showed that TIM-3 polymorphisms (−1516G/T, −574G/T, and +4259T/G) were significantly associated with an increased risk of overall cancer in Chinese Han population. Subgroup analyses based on cancer system showed that TIM-3 −1516G/T polymorphism was only associated with an increased risk of digestive system cancer in Chinese Han population. TIM-3 −574G/T polymorphism was associated with an increased risk of digestive system cancer and other cancer in Chinese Han population. TIM-3 +4259T/G polymorphism was only associated with an increased risk of other cancer in Chinese Han population. In summary, our results indicated that TIM-3 polymorphisms (−1516G/T, −574G/T, and +4259T/G) were associated with the increased risk of cancer in Chinese Han population.
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