The missing link: enhanced functional connectivity between amygdala and visceroceptive cortex in migraine.
The missing link: enhanced functional connectivity between amygdala and visceroceptive cortex in migraine.
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DOI：
10.1177/0333102413490344
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发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Mainero C
中科院分区：
文献类型：
--
作者：
Hadjikhani N;Ward N;Boshyan J;Napadow V;Maeda Y;Truini A;Caramia F;Tinelli E;Mainero C
偏头痛是一种神经血管疾病，其中疼痛调节回路和边缘系统之间的功能连接改变可能起作用。偏头痛先兆的皮质扩散性抑制（CSD）诱导杏仁核C-fos表达。CSD和杏仁核连接在无先兆偏头痛（MwoA）中的作用尚不清楚，可能将偏头痛与其他慢性疼痛疾病区分开来。相对于健康受试者和其他两种与CSD无关的慢性疼痛状况：三叉神经痛（TGN）和腕管综合征（CTS），有先兆的偏头痛（MWA）和MWoA中的杏仁核连接增加到内脏感受性神经元。观察到的边缘/内脏感觉网络内的连接性增加，仅存在于偏头痛患者中，增加了神经边缘疼痛网络功能障碍的证据，并且可能反映了导致偏头痛发展的CSD的重复发作。
Migraine is a neurovascular disorder, in which altered functional connectivity between pain-modulating circuits and the limbic system may play a role. Cortical spreading depression (CSD), which underlies migraine aura induces C-fos expression in the amygdala. The role of CSD, and amygdala connectivity, in migraine without aura (MwoA) is less clear and may differentiate migraine from other chronic pain disorders. Amygdala connectivity in both migraine with aura (MWA) and MWoA was increased to the visceroceptive insula relative to healthy subjects and two other chronic pain conditions not associated with CSD: trigeminal neuralgia (TGN) and carpal tunnel syndrome (CTS). The observed increased connectivity within the limbic/viscerosensory network, present only in migraineurs, adds to the evidence of a neurolimbic pain network dysfunction, and may reflect repetitive episodes of CSD leading to the development of migraine pain.
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影响因子：
3.3
作者：
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通讯作者：
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