Excitatory neurotransmitters in brain regions in interictal migraine patients.
Excitatory neurotransmitters in brain regions in interictal migraine patients.
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DOI：
10.1186/1744-8069-5-34
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发表时间：
2009-06-30
期刊：
影响因子：
3.3
通讯作者：
Borsook D
中科院分区：
文献类型：
--
作者：
Prescot A;Becerra L;Pendse G;Tully S;Jensen E;Hargreaves R;Renshaw P;Burstein R;Borsook D
探讨偏头痛患者间期前扣带皮层（ACC）和脑岛的生化差异。我们假设偏头痛组的兴奋性氨基酸神经递质和/或其衍生物的水平可能存在差异，这是基于偏头痛组对疼痛的敏感性增加。从10例偏头痛患者（7名女性，3名男性，年龄43±11岁）和8例年龄性别匹配的对照组（7名女性，3名男性，年龄41±9岁）在4.0 Tesla (T)下获得了ACC和脑岛的二维j分辨质子磁共振波谱（1H-MRS）数据。包括方差分析（ANOVA）在内的标准统计分析显示，两组受试者在ACC和脑岛的代谢物没有显著差异。然而，线性判别分析（LDA）基于ACC和脑岛中的n -乙酰天冬氨酸（NAAG）和谷氨酰胺（Gln）引入了受试者队列之间的明确分离。与健康对照组相比，这些结果与偏头痛患者在发作间期ACC和脑岛的谷氨酸能异常一致。兴奋性氨基酸神经递质及其衍生物的改变可能是偏头痛患者对偏头痛敏感性降低或慢性偏头痛状态的一个促成因素。这些发现，如果外推到大脑的其他区域，将为这些患者提供新的机会来调节中枢系统作为间歇或先发制人的药物。
To examine biochemical differences in the anterior cingulate cortex (ACC) and insula during the interictal phase of migraine patients. We hypothesized that there may be differences in levels of excitatory amino acid neurotransmitters and/or their derivatives in migraine group based on their increased sensitivity to pain. 2D J-resolved proton magnetic resonance spectroscopy (1H-MRS) data were acquired at 4.0 Tesla (T) from the ACC and insula in 10 migraine patients (7 women, 3 men, age 43 ± 11 years) and 8 age gender matched controls (7 women, 3 men, age 41 ± 9 years). Standard statistical analyses including analysis of variance (ANOVA) showed no significant metabolite differences between the two subject cohorts in the ACC nor the insula. However, linear discriminant analysis (LDA) introduced a clear separation between subject cohorts based on N-acetyl aspartylglutamate (NAAG) and glutamine (Gln) in the ACC and insula. These results are consistent with glutamatergic abnormalities in the ACC and insula in migraine patients during their interictal period compared to healthy controls. An alteration in excitatory amino acid neurotransmitters and their derivatives may be a contributing factor for migraineurs for a decrease in sensitivity for migraine or a consequence of the chronic migraine state. Such findings, if extrapolated to other regions of the brain would offer new opportunities to modulate central system as interictal or preemptive medications in these patients.
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影响因子：
4.9
作者：
DANDREA, G;CANANZI, AR;WELCH, KMA
通讯作者：
WELCH, KMA
影响因子：
11.2
作者：
Burstein, R;Collins, B;Jakubowski, M
通讯作者：
Jakubowski, M
影响因子：
3.7
作者：
Biondi, David M
通讯作者：
Biondi, David M
影响因子：
3.3
作者：
Bussone, G
通讯作者：
Bussone, G
影响因子：
4.9
作者：
CANANZI, AP;DANDREA, G;WELCH, KMA
通讯作者：
WELCH, KMA