Direct laser processing of a tantalum coating on titanium for bone replacement structures.
Direct laser processing of a tantalum coating on titanium for bone replacement structures.
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DOI：
10.1016/j.actbio.2009.11.021
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发表时间：
2010-06
影响因子：
9.7
通讯作者：
Bandyopadhyay, Amit
中科院分区：
文献类型：
--
作者：
Balla, Vamsi Krishna;Banerjee, Shashwat;Bose, Susmita;Bandyopadhyay, Amit
近年来，钽作为一种新型金属生物材料越来越受到人们的关注，因为它被证明具有生物活性和与骨的生物结合。然而，相对较高的制造成本和无法生产模块化的全钽植入物限制了其广泛接受。在这项研究中，我们成功地使用激光工程网成形（LENS™）在Ti上沉积了Ta涂层，以增强骨整合性能。体外生物相容性研究表明，与Ti表面相比，Ta涂层表面表现出良好的细胞粘附和生长，细胞外基质形成丰富。在MMT实验中，Ta涂层上的活细胞密度比Ti对照表面高6倍。高表面能和高润湿性使得Ta表面具有更好的细胞-材料相互作用。此外，由于涂层和基体之间没有孔隙和尖锐的界面，这些致密的Ta涂层不会遭受低抗疲劳性的影响，这是用于增强/早期生物固定的多孔涂层的主要关注点。
Recently, tantalum is gaining more attention as a new metallic biomaterial as it has been shown to be bioactive and biologically bond to the bone. However, relatively high cost of manufacture and inability to produce a modular all tantalum implant has limited'its widespread acceptance. In this study, we have successfully deposited Ta coating on Ti using Laser Engineered Net Shaping (LENS™) to enhance osseointegration properties. In vitro biocompatibility study, using human osteoblast cell line hFOB, showed excellent cellular adherence and growth with abundant extracellular matrix formation on Ta coating surface compare to Ti surface. Six times higher living cell density was observed on Ta coating than on Ti control surface during MMT assay. High surface energy and wettability of Ta surface were observed to contribute to its significantly better cell-materials interactions. Also, these dense Ta coatings do not suffer from low fatigue resistance due to the absence of porosity and sharp interface between the coating and the substrate, which is a major concern for porous coatings used for enhanced/early biological fixation.
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DOI：
10.2106/00004623-199306000-00003
发表时间：
1993-06-01
影响因子：
5.3
作者：
ENGH, CA;ZETTLSCHAFFER, KF;BRAGDON, C
通讯作者：
BRAGDON, C
影响因子：
9.7
作者：
Das, Kakoli;Bose, Susmita;Bandyopadhyay, Amit
通讯作者：
Bandyopadhyay, Amit
DOI：
10.1002/jbm.820241106
发表时间：
1990-11-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
KOHN, DH;DUCHEYNE, P
通讯作者：
DUCHEYNE, P
影响因子：
9.7
作者：
Krishna, B. Vamsi;Xue, Weichang;Bandyopadhyay, Amit
通讯作者：
Bandyopadhyay, Amit
影响因子：
5
作者：
Bermúdez, MD;Carrión, FJ;López, R
通讯作者：
López, R