Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition.
Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition.
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DOI：
10.1016/j.neurobiolaging.2014.07.017
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发表时间：
2015-01
影响因子：
4.2
通讯作者：
Dhenain M
中科院分区：
文献类型：
--
作者：
Roy M;Cardoso C;Dorieux O;Malgorn C;Epelbaum S;Petit F;Kraska A;Brouillet E;Delatour B;Perret M;Aujard F;Dhenain M
阿尔茨海默病（AD）是最常见的与年龄相关的神经退行性疾病。淀粉样蛋白-β肽（a β）在大脑中的沉积是其标志之一，血浆a β的测定被认为是AD动物模型中抗淀粉样蛋白药物疗效的生物标志物。然而，动物模型中与年龄相关的血浆Aβ调节在文献中几乎从未提到过。小鼠狐猴灵长类动物被用作正常和ad样大脑衰老的模型。在此，我们研究了年龄对58只1 ~ 10岁的狐猴血浆Aβ的影响。一部分动物表现出高血浆Aβ，老年动物血浆Aβ高的比例高于幼龄动物。对其中一些动物的大脑进行组织学评估，以评估细胞外和细胞内淀粉样蛋白负荷。在老年狐猴中，血浆Aβ与积累Aβ的神经元密度呈负相关。
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β peptide (Aβ) deposition in the brain is one of its hallmarks and the measure of plasma Aβ is considered to be a biomarker for anti-amyloid drug efficacy in animal models of AD. However, age-associated plasmatic Aβ modulation in animal models is practically never addressed in the literature. Mouse lemur primates are used as a model of normal and AD-like cerebral aging. Here, we studied the effect of age on plasmatic Aβ in 58 mouse lemurs aged from 1 to 10 years. A subset of animals presented high plasmatic Aβ and the proportion of animals with high plasmatic Aβ was higher in aged animals as compared to young ones. Histological evaluation of the brain of some of these animals was carried out to assess extracellular and intracellular amyloid load. In aged lemurs, plasmatic Aβ was negatively correlated with the density of neurons accumulating deposits of Aβ.
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影响因子：
4.2
作者：
Kraska, Audrey;Dorieux, Olene;Picq, Jean-Luc;Petit, Fanny;Bourrin, Emmanuel;Chenu, Evelyne;Volk, Andreas;Perret, Martine;Hantraye, Philippe;Mestre-Frances, Nadine;Aujard, Fabienne;Dhenain, Marc
通讯作者：
Dhenain, Marc
影响因子：
12.7
作者：
Alafuzoff, Irina;Pikkarainen, Maria;Kretzschmar, Hans
通讯作者：
Kretzschmar, Hans
影响因子：
4.2
作者：
Faure, A.;Verret, L.;Delatour, B.
通讯作者：
Delatour, B.
影响因子：
6
作者：
Delatour, B;Mercken, L;Duyckaerts, C
通讯作者：
Duyckaerts, C
影响因子：
12.7
作者：
Duyckaerts C;Potier MC;Delatour B
通讯作者：
Delatour B