Surveillance and correlation of antibiotic consumption and resistance of Acinetobacter baumannii complex in a tertiary care hospital in northeast China, 2003-2011.
Surveillance and correlation of antibiotic consumption and resistance of Acinetobacter baumannii complex in a tertiary care hospital in northeast China, 2003-2011.
复制标题
DOI：
10.3390/ijerph10041462
复制
发表时间：
2013-04-09
影响因子：
--
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Xu J;Sun Z;Li Y;Zhou Q
本研究旨在探讨鲍曼不动杆菌复合菌耐药性的变迁及碳青霉烯类耐药鲍曼不动杆菌复合菌的相关性。2003年至2011年中国东北一家三级医院鲍曼不动杆菌复合体（CRAB）感染和医院抗菌药物使用情况。通过纸片扩散试验测定体外药敏性，并使用临床和实验室标准化研究所（CLSI）推荐的区域直径解释标准测定药敏性特征。从医院药房计算机数据库中回顾性收集各种抗菌药物的消耗数据，表示为定义的每日剂量/1，000例患者/天。2,485株A.鲍曼不动杆菌复合菌主要来源于呼吸道标本（1，618株，65.1%），分泌物和脓液（465株，18.7%）。A.近年来鲍曼不动杆菌复合体显著增加。CRAB发生率为11.3%~ 59.1%。抗假单胞菌碳青霉烯类抗生素的季度使用与季度CRAB的增加密切相关（β = 1.661; p < 0.001），而非其他类别的抗生素。抗假单胞菌碳青霉烯类抗生素的专门使用将是控制CRAB增加的重要干预措施。
This study investigated the changes in resistance of Acinetobacter baumannii complex and the association of carbapenem-resistant A. baumannii complex (CRAB) infection and hospital antimicrobial usage from 2003 to 2011 in a tertiary care hospital in northeast China. In vitro susceptibilities were determined by disk diffusion test and susceptibility profiles were determined using zone diameter interpretive criteria, as recommended by the Clinical and Laboratory Standards Institute (CLSI). Data on consumption of various antimicrobial agents, expressed as defined daily dose/1,000 patients/day, were collected retrospectively from hospital pharmacy computer database. Most of 2,485 strains of A. baumannii complex were collected from respiratory samples (1,618 isolates, 65.1%), secretions and pus (465, 18.7%) over the years. The rates of antimicrobial resistance in A. baumannii complex increased significantly over the years. The rates of CRAB were between 11.3% and 59.1% over the years. The quarterly use of anti-pseudomonal carbapenems, but not other classes of antibiotics, was strongly correlated with the increase of quarterly CRAB (β = 1.661; p < 0.001). Dedicated use of anti-pseudomonal carbapenems would be an important intervention to control the increase of CRAB.
登录
查看更多内容
影响因子：
5.2
作者：
Goel, Neeraj;Wattal, Chand;Prasad, Kamal Jeet
通讯作者：
Prasad, Kamal Jeet
影响因子：
3.7
作者：
Su CH;Wang JT;Hsiung CA;Chien LJ;Chi CL;Yu HT;Chang FY;Chang SC
通讯作者：
Chang SC
DOI：
10.1016/j.diagmicrobio.2008.06.017
发表时间：
2008-11-01
影响因子：
2.9
作者：
Tsai, Hue-Ting;Wang, Jann-Tay;Chang, Shan-Chwen
通讯作者：
Chang, Shan-Chwen
影响因子：
1.6
作者：
Manchanda V;Sanchaita S;Singh N
通讯作者：
Singh N
DOI：
10.5414/cp201595
发表时间：
2011-12-01
影响因子：
0.8
作者：
Song, W.;Cao, J.;Mei, Y. -L.
通讯作者：
Mei, Y. -L.