Clinical and endoscopic characteristics of eosinophilic esophagitis in Japan: a case-control study
Clinical and endoscopic characteristics of eosinophilic esophagitis in Japan: a case-control study
复制标题
日本嗜酸性粒细胞性食管炎的临床和内镜特征：病例对照研究
作者：
Kazumi Imamura;K. Haruma;H. Matsumoto;Yasuhiko Maruyama;Maki Ayaki;Shuhei Tazaki;N. Hisamoto;N. Manabe;T. Kamada;H. Kawamoto
背景嗜酸性粒细胞性食管炎（EoE）是一种与过敏相关的临床病理状况，在世界各地越来越多地得到认可。虽然临床定义和特征可能因国家和地区而异，但在日本尚未进行充分的研究。目的了解日本人群中EoE的患病率及与该病相关的临床特征。方法收集日本9家临床机构2012年1月至2018年10月的内镜资料。EoE，定义为食管粘膜嗜酸性粒细胞每高倍视场至少有15个嗜酸性粒细胞，是根据食管活检确定的。研究了EoE病例的临床和内窥镜模式，并与186名年龄和性别匹配的对照组进行了比较。结果130,013例上颌内镜检查中，发现EoE 66例，占0.051%，平均年龄45.2岁[范围7 ~ 79岁]，男性45例。25例EoE患者（37.9%）在体检时通过内窥镜诊断。与对照组相比，EoE患者出现吞咽困难、食物嵌塞等症状较多（69.7%比10.8%,p < 0.01），过敏反应较多（65.2%比23.7%,p < 0.01）。萎缩性胃炎在EoE患者中的患病率低于对照组（20.0% vs. 33.3%, p < 0.05）。结论日本人群中EoE患病率为0.051%，与日本既往报道相当。过敏史和无萎缩性胃炎与EoE有关。
Background Eosinophilic esophagitis (EoE) is an allergy-associated clinicopathologic condition gaining an increasing amount of recognition in various areas of the world. While the clinical definition and characteristics may differ depending on country and region, sufficient studies have not yet been performed in Japan. Objective To assess the prevalence of EoE among the Japanese population and the clinical features associated with the disease. Methods Endoscopic data from January 2012 to October 2018 was gathered from 9 Japanese clinical institutes. EoE, defined as esophageal mucosal eosinophilia of at least 15 eosinophils per high-power field, was determined based on esophageal biopsies. Clinical and endoscopic patterns in the cases with EoE were investigated and compared with 186 age- and sex-matched controls. Results From 130,013 upper endoscopic examinations, 66 cases of EoE were identified (0.051%; mean age, 45.2 years [range, 7–79 years]; 45 males). Twenty-five patients (37.9%) with EoE were diagnosed by endoscopy during a medical check-up. Patients with EoE had more symptoms (69.7% vs. 10.8%, p < 0.01) such as dysphagia and food impaction, and more allergies (65.2% vs. 23.7%, p < 0.01) compared with the controls. The prevalence of atrophic gastritis was lower in EoE patients than in the controls (20.0% vs. 33.3%, p < 0.05). Conclusion The prevalence of EoE in the Japanese population was 0.051% which was comparable with previous reports in Japan. History of allergies and the absence of atrophic gastritis were associated with EoE.
DOI：
10.1016/j.cgh.2009.06.023
发表时间：
2009-10
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
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作者：
Prasad GA;Alexander JA;Schleck CD;Zinsmeister AR;Smyrk TC;Elias RM;Locke GR 3rd;Talley NJ
通讯作者：
Talley NJ