Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota.
Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota.
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DOI：
10.1016/j.cgh.2009.06.023
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Talley NJ
中科院分区：
文献类型：
--
作者：
Prasad GA;Alexander JA;Schleck CD;Zinsmeister AR;Smyrk TC;Elias RM;Locke GR 3rd;Talley NJ
嗜酸粒细胞性食管炎（EE）的长期趋势和转归数据较为缺乏。我们进行了一项基于人群的研究，以评估明尼苏达州奥姆斯特德县过去30年中EE的流行病学情况和转归。
1976年至2005年间所有确诊的EE病例均通过罗切斯特流行病学项目资源确定。由一名病理学家对有食管炎和/或嗜酸粒细胞浸润证据的食管活检进行复查。临床病程（治疗、反应和复发）通过从病历中收集的信息以及通过电话问卷调查前瞻性地确定。每10万人年的发病率根据美国2000年人口结构按年龄和性别进行直接调整。
共确定了78例EE患者。在5年间隔的最后3个时间段内，EE的发病率显著增加（从1991 - 1995年期间的0.35[0, 0.87]/10万人年增加到2001 - 2005年期间的9.45[7.13, 11.77]/10万人年）。截至2006年1月1日，明尼苏达州奥姆斯特德县EE的患病率为55.0(42.7, 67.2)/10万人。EE在夏末/秋季更常被诊断出。EE患者的临床病程以症状反复发作为特征（在41%的患者中观察到）。
EE的患病率和发病率高于先前报道。在过去30年中，临床诊断的EE发病率显著增加，与内镜检查量和季节性发病率平行，且在夏末/秋季最高。在相当比例的患者中，EE似乎也是一种反复发作的疾病。
Data on secular trends and outcomes of eosinophilic esophagitis (EE) are scarce. We performed a population-based study to assess the epidemiology and outcomes of EE in Olmsted County, Minnesota, over the last 3 decades. All cases of EE diagnosed between 1976 and 2005 were identified using the Rochester Epidemiology Project resources. Esophageal biopsies with any evidence of esophagitis and/or eosinophilic infiltration were reviewed by a single pathologist. Clinical course (treatment, response and recurrence) was defined using information collected from medical records and prospectively via a telephone questionnaire. Incidence rates per 100,000 person years were directly adjusted for age and sex to the US 2000 population structure. A total of 78 patients with EE were identified. The incidence of EE increased significantly over the last 3 of the 5-year intervals (from 0.35 [0,0.87]/100000 person-years during 1991–1995 to 9.45 [7.13, 11.77]/100000 person-years during 2001–2005). The prevalence of EE was 55.0 (42.7, 67.2)/100000 persons as of January 1, 2006 in Olmsted County, Minnesota. EE was diagnosed more frequently in late summer/fall. The clinical course of patients with EE was characterized by recurrent symptoms (observed in 41% of patients). The prevalence and incidence of EE is higher than previously reported. The incidence of clinically diagnosed EE increased significantly over the last 3 decades, in parallel with endoscopy volume and seasonal incidence, and was greatest in late summer/fall. EE also appears to be a recurrent relapsing disease in a substantial proportion of patients.
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