Mesoderm induction and patterning: Insights from neuromesodermal progenitors.
Mesoderm induction and patterning: Insights from neuromesodermal progenitors.
复制标题
中胚层诱导和模式化：来自神经中胚层祖细胞的见解。
DOI：
10.1016/j.semcdb.2021.11.010
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发表时间：
2022-07
影响因子：
7.3
通讯作者：
Martin, Benjamin L.
中科院分区：
文献类型：
--
作者：
Martin, Benjamin L.
关键词：
中胚层诱导信号的发现帮助开创了分子发育生物学时代，如今中胚层诱导和模式化的机制仍在深入研究。中胚层诱导在原肠胚形成期间开始，但最近在脊椎动物中的证据表明，这一过程在原肠胚形成后在一组称为神经中胚层祖细胞（NMP）的后定位细胞中继续进行。NMPs存在于被称为尾芽的原肠胚形成后胚胎结构内，在那里它们在外胚层（脊髓）和中胚层之间做出谱系决定。大多数NMP衍生的中胚层产生体节，但也有助于侧向中胚层的命运，如内皮。NMPs的发现为研究脊椎动物中胚层的诱导提供了一个新的范例。这篇综述将讨论NMPs内中胚层诱导的机制，以及它们如何告知我们对脊椎动物以及脊椎动物谱系外的动物物种中胚层诱导的更广泛的理解。特别关注的是潜在的NMP衍生的中胚层诱导和图案化的信号网络，以及新兴的工作的意义，部分上皮间充质状态协调细胞的命运和形态发生。
The discovery of mesoderm inducing signals helped usher in the era of molecular developmental biology, and today the mechanisms of mesoderm induction and patterning are still intensely studied. Mesoderm induction begins during gastrulation, but recent evidence in vertebrates shows that this process continues after gastrulation in a group of posteriorly localized cells called neuromesodermal progenitors (NMPs). NMPs reside within the post-gastrulation embryonic structure called the tailbud, where they make a lineage decision between ectoderm (spinal cord) and mesoderm. The majority of NMP-derived mesoderm generates somites, but also contributes to lateral mesoderm fates such as endothelium. The discovery of NMPs provides a new paradigm in which to study vertebrate mesoderm induction. This review will discuss mechanisms of mesoderm induction within NMPs, and how they have informed our understanding of mesoderm induction more broadly within vertebrates as well as animal species outside of the vertebrate lineage. Special focus will be given to the signaling networks underlying NMP-derived mesoderm induction and patterning, as well as emerging work on the significance of partial epithelial to mesenchymal states in coordinating cell fate and morphogenesis.
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DOI：
10.1242/dev.037689
发表时间：
2010-11
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Dorey K;Amaya E
通讯作者：
Amaya E
影响因子：
19
作者：
Bakir B;Chiarella AM;Pitarresi JR;Rustgi AK
通讯作者：
Rustgi AK
影响因子：
10.5
作者：
Abu-Abed, S;Dollé, P;Petkovich, M
通讯作者：
Petkovich, M
影响因子：
2.7
作者：
Berenguer, Marie;Lancman, Joseph J.;Duester, Gregg
通讯作者：
Duester, Gregg
影响因子：
7.7
作者：
Dias, Andre;Lozovska, Anastasiia;Mallo, Moises
通讯作者：
Mallo, Moises