Flexibility in motor timing constrains the topology and dynamics of pattern generator circuits.
Flexibility in motor timing constrains the topology and dynamics of pattern generator circuits.
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DOI:
10.1038/s41467-018-03261-5
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发表时间:
2018-03-06
影响因子:
16.6
通讯作者:
Ölveczky BP
中科院分区:
文献类型:
--
作者:
Pehlevan C;Ali F;Ölveczky BP
Temporally precise movement patterns underlie many motor skills and innate actions, yet the flexibility with which the timing of such stereotyped behaviors can be modified is poorly understood. To probe this, we induce adaptive changes to the temporal structure of birdsong. We find that the duration of specific song segments can be modified without affecting the timing in other parts of the song. We derive formal prescriptions for how neural networks can implement such flexible motor timing. We find that randomly connected recurrent networks, a common approximation for how neocortex is wired, do not generally conform to these, though certain implementations can approximate them. We show that feedforward networks, by virtue of their one-to-one mapping between network activity and time, are better suited. Our study provides general prescriptions for pattern generator networks that implement flexible motor timing, an important aspect of many motor skills, including birdsong and human speech. Human speech and bird song requires the generation of precisely timed motor patterns. The authors show that zebra finches can learn to independently modify the duration of individual song segments and find that synfire chain networks are ideally suited to implement such flexible motor timing.
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