Starvation-induced collective behavior in C. elegans.
Starvation-induced collective behavior in C. elegans.
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DOI：
10.1038/srep10647
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发表时间：
2015-05-27
影响因子：
4.6
通讯作者：
Avery L
中科院分区：
文献类型：
--
作者：
Artyukhin AB;Yim JJ;Cheong Cheong M;Avery L
我们在C语言中描述了一种新型的集体行为。线虫，饥饿的L1幼虫聚集。在没有食物的情况下孵化后不久，L1幼虫停止发育并分散寻找食物。相反，在两天或更长时间没有食物后，蠕虫改变了它们的行为它们开始聚集。聚集需要环境中的少量乙醇或乙酸盐。在乙醇的情况下，它必须被代谢，这需要功能性乙醇脱氢酶sodh-1。由此产生的乙酸酯用于从头脂肪酸合成，然后将一些新制备的脂肪酸衍生为甘油磷酸乙醇酰胺并释放到周围介质中。我们研究了其他几个小杆线虫物种，发现饥饿的L1聚集和密度依赖性的生存在饥饿的倾向之间存在明显的相关性。聚集局部集中蠕虫，并可能帮助幼虫生存长期饥饿。这项工作表明，乙醇或乙酸，在环境中相对丰富的小分子的存在下，如何诱导C。与不同的生存策略有关。
We describe a new type of collective behavior in C. elegans nematodes, aggregation of starved L1 larvae. Shortly after hatching in the absence of food, L1 larvae arrest their development and disperse in search for food. In contrast, after two or more days without food, the worms change their behavior—they start to aggregate. The aggregation requires a small amount of ethanol or acetate in the environment. In the case of ethanol, it has to be metabolized, which requires functional alcohol dehydrogenase sodh-1. The resulting acetate is used in de novo fatty acid synthesis, and some of the newly made fatty acids are then derivatized to glycerophosphoethanolamides and released into the surrounding medium. We examined several other Caenorhabditis species and found an apparent correlation between propensity of starved L1s to aggregate and density dependence of their survival in starvation. Aggregation locally concentrates worms and may help the larvae to survive long starvation. This work demonstrates how presence of ethanol or acetate, relatively abundant small molecules in the environment, induces collective behavior in C. elegans associated with different survival strategies.
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影响因子：
9.8
作者：
Chang AJ;Chronis N;Karow DS;Marletta MA;Bargmann CI
通讯作者：
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影响因子：
2.9
作者：
LANGER, SA;GOLDSTEIN, RE;JACKSON, DP
通讯作者：
JACKSON, DP
影响因子：
64.8
作者：
Calignano, A;La Rana, G;Piomelli, D
通讯作者：
Piomelli, D
影响因子：
2.6
作者：
Dominy, NJ
通讯作者：
Dominy, NJ
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影响因子：
3.4
作者：
Félix MA;Jovelin R;Ferrari C;Han S;Cho YR;Andersen EC;Cutter AD;Braendle C
通讯作者：
Braendle C