A distributed chemosensory circuit for oxygen preference in C. elegans.
A distributed chemosensory circuit for oxygen preference in C. elegans.
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DOI：
10.1371/journal.pbio.0040274
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发表时间：
2006-09
期刊：
影响因子：
9.8
通讯作者：
Bargmann CI
中科院分区：
文献类型：
--
作者：
Chang AJ;Chronis N;Karow DS;Marletta MA;Bargmann CI
线虫秀丽线虫对环境氧气、食物和其他动物具有复杂的、自然变化的行为反应。线虫通过可溶性鸟苷环化酶同系物(SGC)检测氧气，并根据神经肽受体NPR-1的活性而做出不同的反应：NPR-1(Lf)和自然分离的NPR-1(215F)动物避免在食物存在下的高氧和聚集；NPR-1(215V)动物不这样做。我们在这里表明，避免高氧通过分布式氧气感应网络的神经调节将食物与NPR-1活性结合在一起。表达sGC的氧敏感神经元、伤害性神经元和ADF感觉神经元刺激高氧回避。在NPR-1(215V)动物中，从食物上的弱趋空性转变为不存在时的强趋空性，需要密切调控ADF神经元中的神经递质5-羟色胺；高水平的ADF-5-羟色胺有助于避免高氧。在NPR-1(Lf)动物中，食物调节被氧气感应神经元活动增加所掩盖。高氧症的避免也受到神经元转化生长因子-β同系物DAF-7的调节，DAF-7是拥挤和应激反应的分泌性中介。DAF-7抑制ADF中5-羟色胺的合成，提示ADF-5-羟色胺是调节高氧避免的一个聚合点。促进和抑制高氧避免的神经元的联合产生了对环境氧气的微妙和灵活的反应。对线虫中调节避免高氧水平的细胞和基因进行系统比较后，发现了一个由促进趋气性和在食物存在时抑制趋气性的神经元组成的分布式网络。
The nematode Caenorhabditis elegans has complex, naturally variable behavioral responses to environmental oxygen, food, and other animals. C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently depending on the activity of the neuropeptide receptor NPR-1: npr-1(lf) and naturally isolated npr-1(215F) animals avoid high oxygen and aggregate in the presence of food; npr-1(215V) animals do not. We show here that hyperoxia avoidance integrates food with npr-1 activity through neuromodulation of a distributed oxygen-sensing network. Hyperoxia avoidance is stimulated by sGC-expressing oxygen-sensing neurons, nociceptive neurons, and ADF sensory neurons. In npr-1(215V) animals, the switch from weak aerotaxis on food to strong aerotaxis in its absence requires close regulation of the neurotransmitter serotonin in the ADF neurons; high levels of ADF serotonin promote hyperoxia avoidance. In npr-1(lf) animals, food regulation is masked by increased activity of the oxygen-sensing neurons. Hyperoxia avoidance is also regulated by the neuronal TGF-β homolog DAF-7, a secreted mediator of crowding and stress responses. DAF-7 inhibits serotonin synthesis in ADF, suggesting that ADF serotonin is a convergence point for regulation of hyperoxia avoidance. Coalitions of neurons that promote and repress hyperoxia avoidance generate a subtle and flexible response to environmental oxygen. A systematic comparison of the cells and genes in C. elegans that mediate avoidance of high oxygen levels reveals a distributed network of neurons that promote aerotaxis and those that suppress it in the presence of food.
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影响因子：
10.5
作者：
Nolan, KM;Sarafi-Reinach, TR;Sengupta, P
通讯作者：
Sengupta, P
DOI：
10.1016/s1532-0456(02)00080-7
发表时间：
2002-12-01
影响因子：
3.9
作者：
Hermes-Lima, M;Zenteno-Savín, T
通讯作者：
Zenteno-Savín, T
影响因子：
3.8
作者：
Fox, HM
通讯作者：
Fox, HM
DOI：
10.1073/pnas.0409009101
发表时间：
2005-03-01
影响因子：
11.1
作者：
Gray, JM;Hill, JJ;Bargmann, CI
通讯作者：
Bargmann, CI
影响因子：
56.9
作者：
HORVITZ, HR;CHALFIE, M;EVANS, PD
通讯作者：
EVANS, PD