Immunohistochemical localization of fibroblast growth factors (FGFs) and FGF receptor-1 in human normal salivary glands and pleomorphic adenomas.
Immunohistochemical localization of fibroblast growth factors (FGFs) and FGF receptor-1 in human normal salivary glands and pleomorphic adenomas.
复制标题
人类正常唾液腺和多形性腺瘤中成纤维细胞生长因子 (FGF) 和 FGF 受体 1 的免疫组织化学定位。
DOI：
--
复制
发表时间：
2007
影响因子：
3.3
通讯作者：
Tamiko Takemura
中科院分区：
文献类型：
--
作者：
K. Kusafuka;Akira Yamaguchi;T. Kayano;Tamiko Takemura
Basic and acidic fibroblast growth factors (bFGF and aFGF) are heparin-binding growth factors, and promote fibrogenesis and angiogenesis. We investigated the immunohistochemical localization of bFGFE, aFGF, and FGF receptor-1 in pleomorphic adenomas. In the normal salivary glands, bFGF was localized in the basement membranes of intercalated ducts, acini and basal cells of the excretory ducts, while aFGF was localized focally in the intercalated ductal cells and basal cells of the excretory ducts. In pleomorphic adenomas, bFGF was immunolocalized in the basement membranes around the solid nests of myoepithelial cells, around the neoplastic myoepithelial cells in the myxoid areas, and in the lacuna cells in the chondroid areas. In contrast, chondroid areas exhibited no immunoreactivity with aFGE. Positive signals for aFGF were localized in luminal cells of the tubuloglandular structures in pleomorphic adenomas. FGF receptor-1 immunolocalized in the lacuna cells and myoepithelial cells in the solid and myxoid areas. These observations suggest that bFGF and FGF receptor-1 produced by myoepithelial cells inhibited terminal differentiation and enchondral ossification in pleomorphic adenomas. These results also suggest important roles for FGFs in the formation of various structures with mesenchymal-like histology.
DOI：
--
发表时间：
1990-12
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
C. C. Cardo-C.;Israel Vlodavsky;A. Friedman;D. Hicklin;Zvi Fuks
通讯作者：
C. C. Cardo-C.;Israel Vlodavsky;A. Friedman;D. Hicklin;Zvi Fuks
影响因子：
--
作者：
Paques, M;Garmyn, V;Gaudric, A
通讯作者：
Gaudric, A