Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function.
Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function.
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DOI：
10.1186/1465-9921-11-28
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发表时间：
2010-03-08
影响因子：
5.8
通讯作者：
Rincon M
中科院分区：
文献类型：
--
作者：
Neveu WA;Allard JL;Raymond DM;Bourassa LM;Burns SM;Bunn JY;Irvin CG;Kaminsky DA;Rincon M
哮喘是一种气道慢性炎症性疾病，其特征在于Th 2型免疫应答，越来越多的证据表明Th 17细胞参与其中。IL-6在促进效应T细胞亚群中的作用表明IL-6可能在哮喘中发挥功能性作用。传统上，IL-6与TNFα和IL-1β沿着被视为炎症标志物，而不是调节性细胞因子。目的探讨IL-6与其他促炎细胞因子、Th 2/Th 17细胞因子在过敏性哮喘中的表达及与肺功能的关系，从而评价IL-6在过敏性哮喘发病中的作用。检测16例健康对照组和18例轻、中度过敏性哮喘患者诱导痰中细胞因子水平和肺功能。促炎性生物标志物TNFα和IL-1β的水平在对照组和哮喘组之间没有差异。相反，与健康对照组相比，哮喘受试者中IL-6水平特异性升高（p < 0.01）。分层回归分析表明，哮喘与肺功能的关系可能是由IL-6介导的。哮喘组Th 2细胞因子中仅IL-13升高（p < 0.05），且与IL-6水平呈正相关（rS = 0.53，p < 0.05）。在轻中度哮喘中，IL-6与其他促炎生物标志物分离，但与IL-13水平相关。此外，IL-6可能有助于变应性哮喘的肺功能受损。
Asthma is a chronic inflammatory disease of the airway that is characterized by a Th2-type of immune response with increasing evidence for involvement of Th17 cells. The role of IL-6 in promoting effector T cell subsets suggest that IL-6 may play a functional role in asthma. Classically IL-6 has been viewed as an inflammatory marker, along with TNFα and IL-1β, rather than as regulatory cytokine. To investigate the potential relationship between IL-6 and other proinflammatory cytokines, Th2/Th17 cytokines and lung function in allergic asthma, and thus evaluate the potential role of IL-6 in this disease. Cytokine levels in induced sputum and lung function were measured in 16 healthy control and 18 mild-moderate allergic asthmatic subjects. The levels of the proinflammatory biomarkers TNFα and IL-1β were not different between the control and asthmatic group. In contrast, IL-6 levels were specifically elevated in asthmatic subjects compared with healthy controls (p < 0.01). Hierarchical regression analysis in the total study cohort indicates that the relationship between asthma and lung function could be mediated by IL-6. Among Th2 cytokines only IL-13 (p < 0.05) was also elevated in the asthmatic group, and positively correlated with IL-6 levels (rS = 0.53, p < 0.05). In mild-moderate asthma, IL-6 dissociates from other proinflammatory biomarkers, but correlates with IL-13 levels. Furthermore, IL-6 may contribute to impaired lung function in allergic asthma.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.4049/jimmunol.0802923
发表时间：
2009-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Neveu WA;Allard JB;Dienz O;Wargo MJ;Ciliberto G;Whittaker LA;Rincon M
通讯作者：
Rincon M
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
5
作者：
Dixon AE;Raymond DM;Suratt BT;Bourassa LM;Irvin CG
通讯作者：
Irvin CG