IL-6 is required for airway mucus production induced by inhaled fungal allergens.
IL-6 is required for airway mucus production induced by inhaled fungal allergens.
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DOI：
10.4049/jimmunol.0802923
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发表时间：
2009-08-01
期刊：
影响因子：
--
通讯作者：
Rincon M
中科院分区：
文献类型：
--
作者：
Neveu WA;Allard JB;Dienz O;Wargo MJ;Ciliberto G;Whittaker LA;Rincon M
过敏性哮喘是由吸入过敏原引起的，其特征在于气道嗜酸性粒细胞增多以及粘液分泌过多，这可导致气流阻塞。尽管IL-6水平升高与人类特应性哮喘相关，但IL-6对吸入性过敏原引发的过敏性气道炎症发展的作用仍不清楚。在这项研究中，我们研究了IL-6在小鼠过敏性气道炎症模型中的作用，该模型由直接气道暴露于人类常见的过敏原烟曲霉提取物诱导。我们在这里表明，吸入A。烟曲霉提取物迅速引发气道中IL-6的产生。在过敏性气道炎症的发展过程中，IL-6似乎与嗜酸性粒细胞向肺的募集有关。然而，IL-6对于气道上皮细胞响应吸入A而触发的粘液高分泌是必需的。烟曲霉抗原由IL-6缺乏引起的粘液产生受损与IL-13水平的严重降低相关，IL-13是粘蛋白糖蛋白的主要诱导物。因此，IL-6是过敏性气道炎症的特定标志性特征的关键调节因子，并且它可能是与杯状细胞化生和粘液分泌过多相关的肺部疾病的潜在靶点。
Allergic asthma is caused by inhaled allergens and it is characterized by airway eosinophilia as well as mucus hypersecretion which can lead to airflow obstruction. Despite the association of increased IL-6 levels with human atopic asthma, the contribution of IL-6 to the development of allergic airway inflammation triggered by inhaled allergens remains unclear. In this study, we examined the role of IL-6 in a mouse model of allergic airway inflammation induced by direct airway exposure to extracts of Aspergillus fumigatus, a common allergen in humans. We show here that inhaled A. fumigatus extracts rapidly triggers the production of IL-6 in the airways. IL-6 appears to be dispensable for the recruitment of eosinophils to the lung during the development of allergic airway inflammation. However, IL-6 is essential for mucus hypersecretion by airway epithelial cells triggered in response to inhaled A. fumigatus antigens. Impaired mucus production caused by IL-6 deficiency correlates with a severe reduction in the levels of IL-13, a major inducer of mucin glycoproteins. Thus, IL-6 is a key regulator of specific hallmark features of allergic airway inflammation, and it could be a potential target for pulmonary diseases that are associated with goblet cell metaplasia and mucus hypersecretion.
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影响因子：
5
作者：
Dixon AE;Raymond DM;Suratt BT;Bourassa LM;Irvin CG
通讯作者：
Irvin CG
影响因子：
4.4
作者：
Li, Hanfen;Willingham, Stephen B.;Ting, Jenny P. -Y.;Re, Fabio
通讯作者：
Re, Fabio
DOI：
10.1084/jem.20081571
发表时间：
2009-01-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dienz O;Eaton SM;Bond JP;Neveu W;Moquin D;Noubade R;Briso EM;Charland C;Leonard WJ;Ciliberto G;Teuscher C;Haynes L;Rincon M
通讯作者：
Rincon M
影响因子：
14.2
作者：
MARINI, M;VITTORI, E;MATTOLI, S
通讯作者：
MATTOLI, S
DOI：
10.1164/rccm.200603-392oc
发表时间：
2006-11-15
影响因子：
24.7
作者：
Kicic, Anthony;Sutanto, Erika N.;Stick, Stephen M.
通讯作者：
Stick, Stephen M.