Of inflammasomes and pathogens--sensing of microbes by the inflammasome.
Of inflammasomes and pathogens--sensing of microbes by the inflammasome.
复制标题
DOI：
10.1002/emmm.201201771
复制
发表时间：
2013-06
影响因子：
11.1
通讯作者：
Hornung, Veit
中科院分区：
文献类型：
--
作者：
Bauernfeind, Franz;Hornung, Veit
炎症体是一种信号传递平台，可以感受到一系列不同的微生物产物，也可以感受到一些与压力和损伤相关的内源性信号。炎症体复合体可以由NOD样受体家族成员或PYHIN家族成员AIM2形成。一旦形成，炎性小体就会触发caspase-1的蛋白分解，随后通过IL-1家族细胞因子的成熟和分泌而导致强烈的炎症反应，这可能伴随着一种称为上睑下垂的炎性细胞死亡。在这里，我们回顾了目前表征的炎性小体复合体的传感机制，并讨论了它们如何参与对微生物病原体的天然免疫反应。我们特别强调在分子理解如何通过炎症体传感器检测微生物模式并将其与内源性化合物区分开来方面的最新进展。进一步，我们回顾了炎性小体如何通过细胞因子依赖和细胞自主机制在抗微生物宿主防御中发挥作用。
Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod-like receptor family or the PYHIN family member AIM2. Upon formation, inflammasomes trigger proteolysis of caspase-1, which subsequently leads to a potent inflammatory response through the maturation and secretion of IL-1 family cytokines, which can be accompanied by an inflammatory cell death termed pyroptosis. Here, we review the sensing mechanisms of the currently characterized inflammasome complexes and discuss how they are involved in the innate immune response against microbial pathogens. We especially highlight recent advances in the molecular understanding of how microbial patterns are detected and discriminated from endogenous compounds by inflammasome sensors. Further, we review how inflammasomes contribute to the anti microbial host defense by cytokine-dependent and cell autonomous mechanisms.
登录
查看更多内容
影响因子：
8.7
作者：
Broz P;Monack DM
通讯作者：
Monack DM
影响因子：
56.9
作者：
Blander, JM;Medzhitov, R
通讯作者：
Medzhitov, R
影响因子：
64.8
作者：
Anand, Paras K.;Malireddi, R. K. Subbarao;Lukens, John R.;Vogel, Peter;Bertin, John;Lamkanfi, Mohamed;Kanneganti, Thirumala-Devi
通讯作者：
Kanneganti, Thirumala-Devi
影响因子：
32.4
作者：
Allen, Irving C.;Scull, Margaret A.;Moore, Chris B.;Holl, Eda K.;McElvania-TeKippe, Erin;Taxman, Debra J.;Guthrie, Elizabeth H.;Pickles, Raymond J.;Ting, Jenny P. -Y.
通讯作者：
Ting, Jenny P. -Y.
影响因子：
32.4
作者：
Agostini, L;Martinon, F;Tschopp, J
通讯作者：
Tschopp, J