Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study.
Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study.
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三甲胺 N-氧化物是一种肠道微生物依赖的胆碱代谢物，与原发性肝癌的风险呈正相关：一项病例对照研究
DOI：
10.1186/s12986-018-0319-2
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发表时间：
2018
影响因子：
4.5
通讯作者：
Zhu HL
中科院分区：
文献类型：
--
作者：
Liu ZY;Tan XY;Li QJ;Liao GC;Fang AP;Zhang DM;Chen PY;Wang XY;Luo Y;Long JA;Zhong RH;Zhu HL
研究背景有证据表明，肠道微生物群产生的胆碱衍生代谢产物--采用高效液相色谱-电喷雾串联质谱法（HPLC-MS/MS）测定血清TMAO和胆碱。这些生物标志物和PLC风险之间的关联进行了评估，使用logistic回归models.ResultsSerum TMAO浓度在PLC组比对照组（P= 0.002）。Logistic回归分析显示，当比较上四分位数和下四分位数（Q4 vs Q1）时，性别和年龄调整的比值比（OR）和（95%置信区间[CI]）为3.43（2.42-4.86）。在进一步调整更多选定的混杂因素后，OR（95% CI）仍然显著，但减弱至2.85（1.59-5.11）（Q4 vs Q1）。胆碱四分位数的多变量校正OR（95%CI）为0.35-0.15（P趋势< 0.001）。这种关联在血清胆碱水平较低的人中更强。需要更多的大型前瞻性研究来证实这些发现。clinicaltrials.gov NCT 03297255 .
BackgroundEvidence has suggested a potential link exists between trimethylamine-N-oxide (TMAO), a choline-derived metabolite produced by gut microbiota, and some cancers, but little is known for primary liver cancer (PLC).MethodsA case-control study was designed including 671 newly diagnosed PLC patients and 671 control subjects frequency-matched by age (±5 years) and sex, in Guangdong province, China. High-performance liquid chromatography with online electrospray ionization tandem mass spectrometry (HPLC-MS/MS) was used to measure serum TMAO and choline. The associations between these biomarkers and PLC risk were evaluated using logistic regression models.ResultsSerum TMAO concentrations were greater in the PLC group than the control group (P= 0.002). Logistic regression analysis showed that the sex- and age-adjusted odds ratio (OR) and (95% confidence interval [CI]) was 3.43 (2.42–4.86) when comparing the top and bottom quartiles (Q4 vs Q1). After further adjusting for more selected confounders, the OR (95% CI) remained significant but was attenuated to 2.85 (1.59–5.11) (Q4 vs Q1). The multivariable-adjusted ORs (95% CIs) across quartiles of choline were 0.35–0.15 (P-trend< 0.001).ConclusionHigher serum levels of TMAO were associated with increased PLC risk. The association was stronger in those with lower serum levels of choline. Additional large prospective studies are required to confirm these findings.Trial registrationThis study was registered at clinicaltrials.gov as NCT 03297255 .
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影响因子：
8.8
作者：
Newman AC;Maddocks ODK
通讯作者：
Maddocks ODK
影响因子：
11.2
作者：
Bae S;Ulrich CM;Neuhouser ML;Malysheva O;Bailey LB;Xiao L;Brown EC;Cushing-Haugen KL;Zheng Y;Cheng TY;Miller JW;Green R;Lane DS;Beresford SA;Caudill MA
通讯作者：
Caudill MA
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3.7
作者：
Lu MS;Fang YJ;Pan ZZ;Zhong X;Zheng MC;Chen YM;Zhang CX
通讯作者：
Zhang CX
影响因子：
9.3
作者：
Holm, PI;Ueland, PM;Lien, EA
通讯作者：
Lien, EA
影响因子：
7.1
作者：
Richman, Erin L.;Kenfield, Stacey A.;Chan, June M.
通讯作者：
Chan, June M.