Choline and betaine intake and colorectal cancer risk in Chinese population: a case-control study.
Choline and betaine intake and colorectal cancer risk in Chinese population: a case-control study.
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DOI：
10.1371/journal.pone.0118661
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zhang CX
中科院分区：
文献类型：
--
作者：
Lu MS;Fang YJ;Pan ZZ;Zhong X;Zheng MC;Chen YM;Zhang CX
很少有研究探讨胆碱和甜菜碱摄入与结直肠癌风险的关系，尽管它们可能在结直肠癌的发展中发挥重要作用，因为它们作为甲基供体的作用。本研究的目的是探讨胆碱和甜菜碱的消费量与中国人群结直肠癌风险之间的关系。2010年7月至2013年12月在中国广州进行了一项病例对照研究。890例连续招募的结直肠癌病例按年龄（间隔5年）和性别与890例对照进行频率匹配。饮食信息进行了评估与验证的食物频率问卷面对面访谈。Logistic回归模型用于估计多变量比值比（OR）和95%置信区间（CI）。调整各种生活方式和饮食因素后，总胆碱摄入量与结直肠癌风险呈负相关。多变量调整OR为0.54（95%CI = 0.37-0.80，Ptrend <0.01），比较最高和最低四分位数。没有观察到甜菜碱或总胆碱+甜菜碱摄入量的显着关联。对于含胆碱的化合物，较低的结直肠癌风险与较高的磷脂酰胆碱、甘油磷酸胆碱和鞘磷脂胆碱摄入量相关，但与游离胆碱和磷酸胆碱无关。在男性和女性结肠癌和直肠癌中观察到总胆碱摄入量与结直肠癌风险呈负相关。叶酸摄入量并没有改变这些负相关。这些结果表明，总胆碱的高摄入量与结直肠癌的低风险有关。
Few studies have examined the association of choline and betaine intake with colorectal cancer risk, although they might play an important role in colorectal cancer development because of their role as methyl donors. The aim of this study was to examine the relationship between consumption of choline and betaine and colorectal cancer risk in a Chinese population. A case-control study was conducted between July 2010 and December 2013 in Guangzhou, China. Eight hundred and ninety consecutively recruited colorectal cancer cases were frequency matched to 890 controls by age (5-year interval) and sex. Dietary information was assessed with a validated food frequency questionnaire by face-to-face interviews. The logistic regression model was used to estimate multivariate odds ratios (ORs) and 95% confidence intervals (CIs). Total choline intake was inversely associated with colorectal cancer risk after adjustment for various lifestyle and dietary factors. The multivariate-adjusted OR was 0.54 (95%CI = 0.37-0.80, Ptrend <0.01) comparing the highest with the lowest quartile. No significant associations were observed for betaine or total choline+betaine intakes. For choline-containing compounds, lower colorectal cancer risk was associated with higher intakes of choline from phosphatidylcholine, glycerophosphocholine and sphingomyelin but not for free choline and phosphocholine. The inverse association of total choline intake with colorectal cancer risk was observed in both men and women, colon and rectal cancer. These inverse associations were not modified by folate intake. These results indicate that high intake of total choline is associated with a lower risk of colorectal cancer.
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