Resolvins as regulators of the immune system.
Resolvins as regulators of the immune system.
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DOI：
10.1100/tsw.2010.72
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发表时间：
2010-05-04
影响因子：
--
通讯作者：
Arita M
中科院分区：
文献类型：
--
作者：
Seki H;Sasaki T;Ueda T;Arita M
炎症是免疫系统对感染或损伤的第一反应，但过度或不适当的炎症反应会导致一系列人类急性和慢性疾病。对膳食补充ω-3多不饱和脂肪酸(即二十碳五烯酸和二十二碳六烯酸)的临床评估表明，它们对这些疾病有有益的影响，尽管在分子水平上对其机制了解甚少。近十年来，研究发现EPA和DHA在急性炎症和消退过程中被酶促转化为生物活性代谢物。这些代谢物被证明在体外和体内都能调节免疫细胞功能，并显示出强大的抗炎作用。因为它们有能力化解急性炎症反应，所以它们被称为前解介质，或解决素。在这篇综述中，我们提供了这些脂质介体的形成和作用的概述。
Inflammation is the first response of the immune system to infection or injury, but excessive or inappropriate inflammatory responses contribute to a range of acute and chronic human diseases. Clinical assessment of dietary supplementation of ω-3 polyunsaturated fatty acids (i.e., eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) indicate that they have beneficial impact on these diseases, although the mechanisms are poorly understood at the molecular level. In this decade, it has been revealed that EPA and DHA are enzymatically converted to bioactive metabolites in the course of acute inflammation and resolution. These metabolites were shown to regulate immune cell functions and to display potent anti-inflammatory actions both in vitro and in vivo. Because of their ability to resolve an acute inflammatory response, they are referred to as proresolving mediators, or resolvins. In this review, we provide an overview of the formation and actions of these lipid mediators.
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