Nitrate and nitrite in biology, nutrition and therapeutics.

Nitrate and nitrite in biology, nutrition and therapeutics.
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DOI:
10.1038/nchembio.260
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发表时间:
2009-12
影响因子:
14.8
通讯作者:
Weitzberg E
Weitzberg E
中科院分区:
生物学1区
文献类型:
--
作者:
Lundberg JO;Gladwin MT;Ahluwalia A;Benjamin N;Bryan NS;Butler A;Cabrales P;Fago A;Feelisch M;Ford PC;Freeman BA;Frenneaux M;Friedman J;Kelm M;Kevil CG;Kim-Shapiro DB;Kozlov AV;Lancaster JR Jr;Lefer DJ;McColl K;McCurry K;Patel RP;Petersson J;Rassaf T;Reutov VP;Richter-Addo GB;Schechter A;Shiva S;Tsuchiya K;van Faassen EE;Webb AJ;Zuckerbraun BS;Zweier JL;Weitzberg E

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Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent two-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.
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