Renin-Angiotensin System and Sex Differences in COVID-19: A Critical Assessment.
Renin-Angiotensin System and Sex Differences in COVID-19: A Critical Assessment.
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DOI：
10.1161/circresaha.123.321883
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发表时间：
2023-05-12
影响因子：
20.1
通讯作者：
Chappell, Mark C.
中科院分区：
文献类型：
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作者：
Chappell, Mark C.
关键词：
目前流行的冠状病毒病(新冠肺炎)已造成巨大的健康负担，成为第三大死亡原因，并可能导致美国人预期寿命的下降。严重急性呼吸综合征相关冠状病毒2与表面结合的肽酶血管紧张素转换酶2(ACE2，EC 3.4.17.23)结合，导致组织感染和病毒复制。ACE2是在肺和其他器官表达的肾素-血管紧张素系统(RAS)的重要酶组分。多肽酶调节相互之间具有截然不同和相反作用的多肽激素Ang II和Ang-(1-7)以及其他心血管多肽的水平。严重急性呼吸综合征相关冠状病毒-2感染的一个潜在后果是通过病毒-血管紧张素转换酶复合体的内化和随后的RAS的激活(更高的血管紧张素II：血管紧张素转换酶-[1-7])而导致血管紧张素转换酶活性降低，这可能加剧新冠肺炎患者的急性炎症事件，并可能参与长新冠肺炎的作用。此外，新冠肺炎患者存在一系列针对RAS各种成分的自身抗体，包括血管紧张素转换酶II、血管紧张素转换酶2和血管紧张素转换酶AT1、AT2和Mas受体。男性新冠肺炎患者的疾病严重程度也更高，这可能反映了RAS两个不同功能臂的调节方面的潜在性别差异。目前的综述对新冠肺炎受试者中激活的RAS的证据以及这一系统是否导致男性严重急性呼吸综合征相关冠状病毒-2感染比女性更严重进行了关键的评估。
The current epidemic of corona virus disease (COVID-19) has resulted in an immense health burden that became the third leading cause of death and potentially contributed to a decline in life expectancy in the United States. The severe acute respiratory syndrome-related coronavirus-2 binds to the surface-bound peptidase angiotensin-converting enzyme 2 (ACE2, EC 3.4.17.23) leading to tissue infection and viral replication. ACE2 is an important enzymatic component of the renin-angiotensin system (RAS) expressed in the lung and other organs. The peptidase regulates the levels of the peptide hormones Ang II and Ang-(1–7), which have distinct and opposing actions to one another, as well as other cardiovascular peptides. A potential consequence of severe acute respiratory syndrome-related coronavirus-2 infection is reduced ACE2 activity by internalization of the viral-ACE2 complex and subsequent activation of the RAS (higher ratio of Ang II:Ang-[1–7]) that may exacerbate the acute inflammatory events in COVID-19 patients and possibly contribute to the effects of long COVID-19. Moreover, COVID-19 patients present with an array of autoantibodies to various components of the RAS including the peptide Ang II, the enzyme ACE2, and the AT1 AT2 and Mas receptors. Greater disease severity is also evident in male COVID-19 patients, which may reflect underlying sex differences in the regulation of the 2 distinct functional arms of the RAS. The current review provides a critical evaluation of the evidence for an activated RAS in COVID-19 subjects and whether this system contributes to the greater severity of severe acute respiratory syndrome-related coronavirus-2 infection in males as compared with females.
影响因子：
12.7
作者：
Serpa Neto, Ary;Landoni, Giovanni;Ostermann, Marlies;Lumlertgul, Nuttha;Forni, Lui;Alvarez-Belon, Lucas;Trapani, Tony;Alliegro, Patricia, V;Zacharowski, Kai;Wiedenbeck, Carolin;de Backer, Daniel;Bellomo, Rinaldo
通讯作者：
Bellomo, Rinaldo
DOI：
10.1016/j.hlc.2020.11.008
发表时间：
2021-06
期刊：
Heart, lung & circulation
影响因子：
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作者：
Triposkiadis F;Starling RC;Xanthopoulos A;Butler J;Boudoulas H
通讯作者：
Boudoulas H
影响因子：
3.6
作者：
通讯作者：
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