Testosterone Level Reduction Increases the 10-Year Risk of Cardiovascular Diseases: A Retrospective Cohort Study in a Taiwanese Young Male Population.
Testosterone Level Reduction Increases the 10-Year Risk of Cardiovascular Diseases: A Retrospective Cohort Study in a Taiwanese Young Male Population.
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DOI：
10.3389/fcvm.2022.869251
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发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
低睾酮水平与心血管疾病风险增加相关;然而，大多数既往研究评估了睾酮水平与心血管（CV）事件史的关系，而不是与CV风险预测评分的关系，因此忽略了睾酮对健康年轻个体CV风险的影响。这项研究的目的是调查睾酮水平之间的关系，并预测10年心血管疾病的风险。这项回顾性队列研究是通过台湾四个大都市的大型医疗健康检查系统进行的。两种风险评分用于预测参与者的10年心血管风险：Fragrance风险评分（FRS）（2008）和动脉粥样硬化性心血管疾病（ASCVD）风险估计（2013）。使用多变量校正的logistic回归计算睾酮水平降低与预测CV风险增加相关性的比值比（OR）。我们使用MJ健康研究基金会数据库收集了2007年至2016年期间接受体检的125，414人的报告。最终样本量包括1，253名男性参与者。在30-49岁的年轻受试者中，两次后续医学检查之间的睾酮水平降低与FRS和ASCVD风险估计值估计的较高CV风险相关（分别为OR = 0.804，95%CI：0.711-0.909，p < 0.01和OR = 0.841，95%CI：0.742-0.953，p < 0.01）。总睾酮水平降低会增加30至49岁男性的CV风险，而CV风险不受基线睾酮水平低的影响。
Low testosterone levels are associated with increased risk of cardiovascular disease; however, most previous studies assessed the relationship of testosterone levels with a history of cardiovascular (CV) events rather than with CV risk prediction scores consequently neglecting the effect of testosterone on CV risk in healthy young individuals. The aim of this study was to investigate the relationship between testosterone levels and predict the 10-year risk of cardiovascular disease. This retrospective cohort study was conducted through a large medical health examination system in four metropolises in Taiwan. Two risk scores were used to predict the 10-year cardiovascular risk of participants: the Framingham Risk Score (FRS) (2008) and the Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator (2013). Multivariate-adjusted logistic regression was used to calculate odds ratios (ORs) for the correlation of testosterone level reduction with the increase in predicted CV risk. We used the MJ Health Research Foundation database to collect reports of 125,414 individuals who underwent medical checkups between 2007 and 2016. The final sample size included 1,253 male participants. A reduction in testosterone level between two subsequent medical checkups was associated with higher CV risk estimated by the FRS and ASCVD Risk Estimator in young participants aged 30–49 years (OR = 0.804, 95% CI: 0.711–0.909, p < 0.01 and OR = 0.841, 95% CI: 0.742–0.953, p < 0.01, respectively). Reduction in total testosterone levels increases CV risk in men aged 30 to 49 years, while the CV risk is not influenced by low testosterone levels at baseline.
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影响因子：
24
作者：
Ford, ES;Giles, WH;Mokdad, AH
通讯作者：
Mokdad, AH
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作者：
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通讯作者：
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作者：
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