Metabolic positron emission tomography imaging in cancer detection and therapy response.
Metabolic positron emission tomography imaging in cancer detection and therapy response.
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DOI：
10.1053/j.seminoncol.2010.11.012
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发表时间：
2011-02
影响因子：
4
通讯作者：
Shim H
中科院分区：
文献类型：
--
作者：
Zhu A;Lee D;Shim H
正电子发射断层扫描 (PET) 是一种无创成像技术，可对正常组织或疾病状况进行功能或代谢评估。由于大多数类型肿瘤的葡萄糖代谢增加，18F-氟脱氧葡萄糖 PET 成像（FDG-PET）在临床上广泛用于肿瘤成像，并已被证明可以改善癌症的诊断和后续治疗。在本章中，我们回顾了它在癌症诊断、分期、再分期和治疗反应评估中的应用。此外，还讨论了处于研究或临床试验阶段的其他代谢PET显像剂，包括基于增加蛋白质合成的氨基酸类似物，以及基于增加膜脂合成的胆碱。氨基酸类似物和胆碱比 FDG 对肿瘤细胞更具特异性，因此它们在区分癌症与良性疾病以及诊断低 FDG 摄取或高背景 FDG 摄取的癌症方面发挥着重要作用。几十年来，研究人员已经证明，肿瘤已经改变了代谢特征，并显示出葡萄糖、氨基酸和脂质的摄取增加，这可用于癌症诊断和监测治疗反应，并具有出色的信噪比。
Positron emission tomography (PET) is a noninvasive imaging technique that provides a functional or metabolic assessment of normal tissue or disease conditions. 18F-fluorodeoxyglucose PET imaging (FDG-PET) is widely used clinically for tumor imaging due to increased glucose metabolism in most types of tumors, and has been shown to improve the diagnosis and subsequent treatment of cancers. In this chapter, we review its use in cancer diagnosis, staging, restaging, and assessment of response to treatment. In addition, other metabolic PET imaging agents in research or clinical trial stages are discussed, including amino acid analogs based on increased protein synthesis, and choline, which is based on increased membrane lipid synthesis. Amino acid analogs and choline are more specific to tumor cells than FDG, so they play an important role in differentiating cancers from benign conditions and in the diagnosis of cancers with low FDG uptake or high background FDG uptake. For decades, researchers have shown that tumors have altered metabolic profiles and display elevated uptake of glucose, amino acids, and lipids, which can be used for cancer diagnosis and monitoring of the therapeutic response with excellent signal-to-noise ratios.
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DOI：
10.1007/s00259-004-1531-z
发表时间：
2004-06-01
影响因子：
9.1
作者：
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DOI：
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发表时间：
2006-01-01
影响因子：
9.1
作者：
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通讯作者：
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DOI：
10.1007/s00259-003-1259-1
发表时间：
2003-11-01
影响因子：
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通讯作者：
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