Nicotine signaling and progression of chronic kidney disease in smokers.
Nicotine signaling and progression of chronic kidney disease in smokers.
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DOI：
10.1016/j.bcp.2013.07.014
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发表时间：
2013-10-15
影响因子：
5.8
通讯作者：
Jaimes, Edgar A.
中科院分区：
文献类型：
--
作者：
Jain, Gaurav;Jaimes, Edgar A.
吸烟对健康的有害影响是深远的，它仍然是改善总体发病率和死亡率的最重要的可改变的风险因素。除了是癌症、心血管疾病和肺部疾病的危险因素外，来自人类和动物的研究也有强有力的证据表明，吸烟在慢性肾脏疾病(CKD)的进展中起到了作用。临床研究表明，吸烟与糖尿病、高血压、多囊肾病和肾移植后CKD恶化有很强的相关性。尼古丁除了在吸烟的成瘾特性中发挥作用外，还通过激活非神经性烟碱型乙酰胆碱受体(NAChRs)具有其他生物学效应。在正常肾脏中有几个α受体亚基的表达，阻断其7-nAChR亚基可改善尼古丁对慢性肾脏病动物模型的影响。尼古丁增加了包括急性肾损伤、糖尿病、急性肾炎和肾大部切除术在内的动物模型中肾脏损伤的严重程度。尼古丁对肾脏的影响还与增加活性氧的生成和激活促纤维化途径有关。在人类中，尼古丁导致血压一过性升高，并伴随着肾小球滤过率和有效肾血浆流量的下降。综上所述，临床和实验证据表明，尼古丁至少在一定程度上导致了吸烟在慢性肾脏病进展过程中的有害影响。所涉及的机制是积极研究的主题，并可能导致新的策略来改善吸烟对慢性肾脏病的影响。
The deleterious health effects of cigarette smoking are far reaching, and it remains the most important modifiable risk factor for improving overall morbidity and mortality. In addition to being a risk factor for cancer, cardiovascular disease and lung disease, there is strong evidence, both from human and animal studies, demonstrating a role for cigarette smoking in the progression of chronic kidney disease (CKD). Clinical studies have shown a strong correlation between cigarette smoking and worsening CKD in patients with diabetes, hypertension, polycystic kidney disease, and post kidney transplant. Nicotine, in addition to its role in the addictive properties of cigarette smoking, has other biological effects via activation of non-neuronal nicotinic acetylcholine receptors (nAChRs). Several nAChR subunits are expressed in the normal kidney and blockade of the α7-nAChR subunit ameliorates the effects of nicotine in animal models of CKD. Nicotine increases the severity of renal injury in animal models including acute kidney injury, diabetes, acute nephritis and subtotal nephrectomy. The renal effects of nicotine are also linked to increased generation of reactive oxygen species and activation of pro-fibrotic pathways. In humans, nicotine induces transitory increases in blood pressure accompanied by reductions in glomerular filtration rate and effective renal plasma flow. In summary, clinical and experimental evidence indicate that nicotine is at least in part responsible for the deleterious effects of cigarette smoking in the progression of CKD. The mechanisms involved are the subject of active investigation and may result in novel strategies to ameliorate the effects of cigarette smoking in CKD.
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DOI：
10.1006/bbrc.1999.0478
发表时间：
1999-04-13
影响因子：
3.1
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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