Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy.
Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy.
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DOI：
10.1080/15384101.2017.1371886
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发表时间：
2017-10-02
期刊：
影响因子：
--
通讯作者：
Xia Z
中科院分区：
文献类型：
--
作者：
Cai Y;Kandula V;Kosuru R;Ye X;Irwin MG;Xia Z
哺乳动物Rap1是最保守的端粒相互作用蛋白，除了在细胞核内维持端粒功能外，还因其在与代谢、炎症和氧化应激相关的各种生理和病理条件下的多效性功能而闻名。对于所有这些，如今Rap1是关键研究的主题，旨在揭示其分子信号传导途径，并审查其调节作为具有临床相关性的有前途的治疗策略的适用性。然而，Rap1的潜在内在机制尚未得到广泛研究，但这种蛋白质水平的任何调节都与炎症，氧化应激和代谢失调等病理学有关。鉴于最近发现Rap1在癌症和心脏代谢紊乱等疾病中的调节作用，这一点非常重要。在这篇综述中，我们专注于Rap1的端粒和非端粒功能及其在各种健康风险，特别是对心脏的调制。
Mammalian Rap1, the most conserved telomere-interacting protein, beyond its role within nucleus for the maintenance of telomeric functions, is also well known for its pleiotropic functions in various physiological and pathological conditions associated with metabolism, inflammation and oxidative stress. For all these, nowadays Rap1 is the subject of critical investigations aimed to unveil its molecular signaling pathways and to scrutinize the applicability of its modulation as a promising therapeutic strategy with clinical relevance. However, the underlying intimate mechanisms of Rap1 are not extensively studied, but any modulation of this protein level has been associated with pathologies like inflammation, oxidative stress and deregulated metabolism. This is considerably important in light of the recent discovery of Rap1 modulation in diseases like cancer and cardiac metabolic disorders. In this review, we focus on both the telomeric and nontelomeric functions of Rap1 and its modulation in various health risks, especially on the heart.
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影响因子：
14.9
作者：
Janoušková E;Nečasová I;Pavloušková J;Zimmermann M;Hluchý M;Marini V;Nováková M;Hofr C
通讯作者：
Hofr C
影响因子：
4.8
作者：
Eisele, Petra S.;Salatino, Silvia;Handschin, Christoph
通讯作者：
Handschin, Christoph
影响因子：
56.9
作者：
Brunet, A;Sweeney, LB;Greenberg, ME
通讯作者：
Greenberg, ME
影响因子：
14.9
作者：
CHAMBERS, A;STANWAY, C;KINGSMAN, SM
通讯作者：
KINGSMAN, SM
白细胞端粒长度的纵向下降，与性别和遗传风险相关。
DOI：
10.18632/aging.100995
发表时间：
2016-07
期刊：
Aging
影响因子：
--
作者：
Berglund K;Reynolds CA;Ploner A;Gerritsen L;Hovatta I;Pedersen NL;Hägg S
通讯作者：
Hägg S