Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study.
Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study.
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DOI：
10.1016/j.jcf.2020.11.021
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Brodlie M
中科院分区：
文献类型：
--
作者：
Bain R;Cosgriff R;Zampoli M;Elbert A;Burgel PR;Carr SB;Castaños C;Colombo C;Corvol H;Faro A;Goss CH;Gutierrez H;Jung A;Kashirskaya N;Marshall BC;Melo J;Mondejar-Lopez P;de Monestrol I;Naehrlich L;Padoan R;Pastor-Vivero MD;Rizvi S;Salvatore M;Filho LVRFDS;Brownlee KG;Haq IJ;Brodlie M
包括潜在呼吸系统问题在内的合并症已被确定为严重COVID-19疾病的危险因素。关于囊性纤维化（CF）儿童中SARS-CoV-2感染的临床过程的信息有限，但对于为CF儿童、其家庭、护理人员和临床团队提供准确的建议至关重要。CF登记全球协调小组在2020年2月1日至8月7日期间整理了13个国家的18岁以下CF儿童中SARS-CoV-2感染病例。对105名儿童的数据进行了整理和分析。病例的中位年龄为10岁（四分位数范围为6-15），54%为男性，预测一秒钟用力呼气量的中位百分比为94%（四分位数范围为79-104）。大多数（71%）儿童在感染COVID-19期间在社区得到了治疗。入院的24名儿童中，6名需要补充氧气，2名需要无创通气。大约一半的儿童服用了抗生素，5名儿童接受了抗病毒治疗，4名接受了阿奇霉素治疗，1名接受了额外的皮质类固醇治疗。住院儿童的肺功能较低，体重指数z分数也较低。一名儿童在SARS-CoV-2检测呈阳性六周后死亡，病情恶化并非归因于COVID-19疾病。患有CF的儿童感染SARS-CoV-2通常与那些先前没有严重肺部疾病的儿童的轻微疾病有关。
The presence of co-morbidities, including underlying respiratory problems, has been identified as a risk factor for severe COVID-19 disease. Information on the clinical course of SARS-CoV-2 infection in children with cystic fibrosis (CF) is limited, yet vital to provide accurate advice for children with CF, their families, caregivers and clinical teams. Cases of SARS-CoV-2 infection in children with CF aged less than 18 years were collated by the CF Registry Global Harmonization Group across 13 countries between 1 February and 7 August 2020. Data on 105 children were collated and analysed. Median age of cases was ten years (interquartile range 6–15), 54% were male and median percentage predicted forced expiratory volume in one second was 94% (interquartile range 79–104). The majority (71%) of children were managed in the community during their COVID-19 illness. Out of 24 children admitted to hospital, six required supplementary oxygen and two non-invasive ventilation. Around half were prescribed antibiotics, five children received antiviral treatments, four azithromycin and one additional corticosteroids. Children that were hospitalised had lower lung function and reduced body mass index Z-scores. One child died six weeks after testing positive for SARS-CoV-2 following a deterioration that was not attributed to COVID-19 disease. SARS-CoV-2 infection in children with CF is usually associated with a mild illness in those who do not have pre-existing severe lung disease.
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影响因子：
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