Clonally related cells are restricted to organ boundaries early in the development of the chicken gut to form compartment boundaries.
Clonally related cells are restricted to organ boundaries early in the development of the chicken gut to form compartment boundaries.
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在鸡肠道发育早期，克隆相关细胞被限制在器官边界内，形成区室边界。
作者：
D. M. Smith;C. Tabin
肠道器官都是从一个简单的、未分化的、线性的肠管中衍生出来的。我们分析了鸡胚胎中来自这个肠管的细胞的谱系关系，确定了单个细胞的后代在肠道中的位置。我们发现，来自单个祖细胞的子代细胞在发育早期可以同时存在于胃(鸡胃)和小肠中，但克隆相关细胞在第12阶段被限制在单个器官中。我们还发现，在这些实验中测试的所有阶段，克隆相关细胞都可以分布在肠道放射轴内的不同中胚层。许多在肠道中具有器官特异性表达模式的基因已经被分离出来。这些限制性表达模式的出现与克隆边界似乎形成的时间相关，这表明这些基因可能参与了间隔边界的建立，从而防止边界一侧的细胞与边界另一侧的细胞混合。
The gut organs are all derived from a simple, undifferentiated, linear gut tube. We analyzed the lineage relationships of cells derived from this gut tube in chicken embryos, determining where the progeny of a single cell are located within the gut. We find that daughter cells derived from a single progenitor can populate both the gizzard (chicken stomach) and the small intestine early in development, but that clonally related cells are restricted to a single organ by stage 12. We also find that clonally related cells can populate different mesodermal layers within the radial axis of the gut throughout all of the stages tested in these experiments. Many genes that have organ-specific expression patterns within the gut have been isolated. The onset of these restricted expression patterns correlates with the time that clonal boundaries appear to form, suggesting that these genes might be involved in the establishment of compartment boundaries, which prevent cells on one side of the boundary from intermingling with cells on the other side of the boundary.
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DOI：
10.1242/dev.120.6.1347
发表时间：
1994
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Birgbauer,E;Fraser,SE
通讯作者：
Fraser,SE
鸡肠道区域化过程中的上皮间质信号传导。
DOI：
10.1242/dev.125.15.2791
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Roberts,DJ;Smith,DM;Goff,DJ;Tabin,CJ
通讯作者：
Tabin,CJ
影响因子：
4.6
作者：
M. F. Offield;T. Jetton;P. Labosky;M. Ray;R. Stein;M. Magnuson;B. Hogan;C. Wright
通讯作者：
M. F. Offield;T. Jetton;P. Labosky;M. Ray;R. Stein;M. Magnuson;B. Hogan;C. Wright
DOI：
10.1073/pnas.93.12.6191
发表时间：
1996-06-11
影响因子：
11.1
作者：
Dymecki, SM
通讯作者：
Dymecki, SM
DOI：
10.1073/pnas.92.12.5704
发表时间：
1995-06-06
影响因子：
11.1
作者：
GOLDEN, JA;FIELDSBERRY, SC;CEPKO, CL
通讯作者：
CEPKO, CL