Superinfection exclusion and the long-term survival of honey bees in Varroa-infested colonies.

Superinfection exclusion and the long-term survival of honey bees in Varroa-infested colonies.
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DOI:
10.1038/ismej.2015.186
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发表时间:
2016-05
期刊:
The ISME journal
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其他
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在过去的50年里,由于体外寄生螨狄斯瓦螨在世界各地的传播,数百万欧洲蜜蜂(Apis mellifera)的蜂群已经死亡。随后的研究表明,螨与一组RNA病毒病原体(畸形翼病毒,DWV)的关联与菌落死亡相关。在这里,我们提出了一种被称为重复感染排除的现象,它提供了一个解释,为什么某些A。尽管瓦螨属侵染和高DWV负荷,意大利蜜蜂种群仍然存活。下一代测序表明,非致死性DWV变体“B型”已在这些菌落中建立,而致死性“A型”DWV变体未能在蜜蜂种群中持续存在。我们提出,这种新的稳定的宿主-病原体关系可以防止致死性变体的积累,这表明这种相互作用可以用于开发一种有效的治疗方法,以最大限度地减少未来的菌落损失。
Over the past 50 years, many millions of European honey bee (Apis mellifera) colonies have died as the ectoparasitic mite, Varroa destructor, has spread around the world. Subsequent studies have indicated that the mite's association with a group of RNA viral pathogens (Deformed Wing Virus, DWV) correlates with colony death. Here, we propose a phenomenon known as superinfection exclusion that provides an explanation of how certain A. mellifera populations have survived, despite Varroa infestation and high DWV loads. Next-generation sequencing has shown that a non-lethal DWV variant ‘type B' has become established in these colonies and that the lethal ‘type A' DWV variant fails to persist in the bee population. We propose that this novel stable host-pathogen relationship prevents the accumulation of lethal variants, suggesting that this interaction could be exploited for the development of an effective treatment that minimises colony losses in the future.
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