Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.
Marine pharmacology in 2005-6: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.
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DOI：
10.1016/j.bbagen.2009.03.011
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发表时间：
2009-05
影响因子：
3
通讯作者：
Hamann, Mark T.
中科院分区：
文献类型：
--
作者：
Mayer, Alejandro M. S.;Rodriguez, Abimael D.;Berlinck, Roberto G. S.;Hamann, Mark T.
该综述介绍了2005-2006年同行评审的海洋药理学文献，并遵循与作者1998-2004年综述相似的格式。系统地介绍了从海洋动物、藻类、真菌和细菌中分离的化学特征海洋化合物的临床前药理学。本文报道了78种海洋化学品的驱虫、抗菌、抗凝血、抗真菌、抗疟疾、抗原虫、抗结核和抗病毒活性。此外，据报道，47种海洋化合物会影响心血管、免疫和神经系统，并具有抗炎作用。最后，58种海洋化合物被证明与各种分子靶点结合，因此可能有助于几种药理学类别。2005-2006年期间的海洋药理学研究确实是全球性的，有来自32个国家和美国的研究人员参与，为旨在发现新治疗剂的研究管道提供了183条海洋化学线索。继续对海洋天然产品进行临床前和临床研究，证明其具有广泛的药理活性，并可能产生用于治疗多种疾病的新型治疗剂。
The review presents the 2005–2006 peer-reviewed marine pharmacology literature, and follows a similar format to the authors’ 1998–2004 reviews. The preclinical pharmacology of chemically characterized marine compounds isolated from marine animals, algae, fungi and bacteria is systematically presented. Anthelminthic, antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 78 marine chemicals. Additionally 47 marine compounds were reported to affect the cardiovascular, immune and nervous system as well as possess anti-inflammatory effects. Finally, 58 marine compounds were shown to bind to a variety of molecular targets, and thus could potentially contribute to several pharmacological classes. Marine pharmacology research during 2005–2006 was truly global in nature, involving investigators from 32 countries, and the United States, and contributed 183 marine chemical leads to the research pipeline aimed at the discovery of novel therapeutic agents. Continued preclinical and clinical research with marine natural products demonstrating a broad spectrum of pharmacological activity and will probably result in novel therapeutic agents for the treatment of multiple disease categories.
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影响因子：
4.3
作者：
Bickmeyer, U;Assmann, M;Schütt, C
通讯作者：
Schütt, C
影响因子：
5.1
作者：
Capon, RJ;Vuong, D;Gill, JH
通讯作者：
Gill, JH
影响因子：
3.8
作者：
Adhikari, Utpal;Mateii, Cecilia G.;Ray, Bimalendu
通讯作者：
Ray, Bimalendu
DOI：
10.1073/pnas.0504249102
发表时间：
2005-07-26
影响因子：
11.1
作者：
Bordeleau, ME;Matthews, J;Pelletier, J
通讯作者：
Pelletier, J
影响因子：
5.6
作者：
Arena, A;Maugeri, TL;Bisignano, G
通讯作者：
Bisignano, G