Oxidative Stress: Harms and Benefits for Human Health.
Oxidative Stress: Harms and Benefits for Human Health.
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DOI：
10.1155/2017/8416763
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发表时间：
2017
影响因子：
--
通讯作者：
Bitto A
中科院分区：
文献类型：
--
作者：
Pizzino G;Irrera N;Cucinotta M;Pallio G;Mannino F;Arcoraci V;Squadrito F;Altavilla D;Bitto A
氧化应激是由细胞和组织中氧反应性物质（ROS）的产生和积累与生物系统解毒这些反应性产物的能力之间的不平衡引起的现象。ROS可以发挥，事实上它们确实发挥了几种生理作用（即，细胞信号），并且它们通常作为氧代谢的副产物产生;尽管如此，环境应激源（即，紫外线、电离辐射、污染物和重金属）和异生物质（即，抗胚细胞药物）有助于大大增加ROS的产生，因此引起导致细胞和组织损伤（氧化应激）的不平衡。近年来，几种抗氧化剂因其对氧化应激的实际或假定的有益作用而被开发，如维生素E、类黄酮和多酚。虽然我们倾向于将氧化应激描述为对人体有害，但它也被用作治疗癌症等临床疾病的治疗方法，并取得了一定程度的临床成功。在这篇综述中，我们将描述氧化应激领域的最新研究结果，突出其对人类健康的坏和好的方面。
Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products. ROS can play, and in fact they do it, several physiological roles (i.e., cell signaling), and they are normally generated as by-products of oxygen metabolism; despite this, environmental stressors (i.e., UV, ionizing radiations, pollutants, and heavy metals) and xenobiotics (i.e., antiblastic drugs) contribute to greatly increase ROS production, therefore causing the imbalance that leads to cell and tissue damage (oxidative stress). Several antioxidants have been exploited in recent years for their actual or supposed beneficial effect against oxidative stress, such as vitamin E, flavonoids, and polyphenols. While we tend to describe oxidative stress just as harmful for human body, it is true as well that it is exploited as a therapeutic approach to treat clinical conditions such as cancer, with a certain degree of clinical success. In this review, we will describe the most recent findings in the oxidative stress field, highlighting both its bad and good sides for human health.
影响因子：
8.8
作者：
Migliozzi, J A
通讯作者：
Migliozzi, J A