Microenvironmental interactions of oligodendroglial cells.

Microenvironmental interactions of oligodendroglial cells.
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少突胶质细胞的微环境相互作用。

DOI:
10.1016/j.devcel.2021.06.006
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发表时间:
2021-07-12
期刊:
影响因子:
11.8
通讯作者:
Monje M
Monje M
中科院分区:
生物学1区
文献类型:
--
作者:
Yalçın B;Monje M

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发育性髓鞘形成是一个长期的过程,一直延伸到出生后的生活。细胞内在机制在形成髓鞘的少突胶质细胞中起作用,以及指导和调节髓鞘形成各个方面的微环境相互作用,从少突胶质细胞前体细胞迁移到少突胶质细胞分化和稳定髓鞘节间的形成。在发育过程中和整个成年生活中,神经元-少突胶质细胞相互作用塑造活动和经验依赖性髓磷脂适应,以微调神经回路动态并促进健康的神经功能。
Developmental myelination is a protracted process that extends well into postnatal life. Cell-intrinsic mechanisms operate in myelin-forming oligodendrocytes, as well as microenvironmental interactions that guide and modulate every aspect of myelination, from oligodendrocyte precursor cell migration to oligodendrocyte differentiation and the formation of stable myelin internodes. During development and throughout adult life, neuron-oligodendroglial interactions shape activity and experience-dependent myelin adaptations to fine tune neural circuit dynamics and promote healthy neurological function.
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发表时间: 2010-03-10
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