Targeted renal therapies through microbubbles and ultrasound.
Targeted renal therapies through microbubbles and ultrasound.
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DOI：
10.1016/j.addr.2010.10.002
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发表时间：
2010-11-30
影响因子：
16.1
通讯作者：
Sharma, Kumar
中科院分区：
文献类型：
--
作者：
Deelman, Leo E.;Decleves, Anne-Emilie;Rychak, Joshua J.;Sharma, Kumar
关键词：
微泡和超声波增强药物（包括基因构建体）进入肾脏的细胞摄取。微泡诱导的对肾脏过滤能力的大小选择性的改变可使药物能够进入先前不可接近的肾脏隔室。到目前为止，仅在大鼠中报告了毛细血管出血等负面肾脏副作用，在猪和兔等较大模型中没有明显损害。虽然局部递送是通过仅将超声施加到目标区域来实现的，但是使用常规微泡的有效递送依赖于将药物和微泡两者直接组合注射到肾动脉中。抗体与微泡壳的缀合允许微泡在静脉内注射后在靶组织中特异性积聚。这种令人兴奋的方法为药物输送和肾脏超声诊断成像开辟了新的可能性。
Microbubbles and ultrasound enhance the cellular uptake of drugs (including gene constructs) into the kidney. Microbubble induced modifications to the size selectivity of the filtration capacity of the kidney may enable drugs to enter previously inaccessible compartments of the kidney. So far, negative renal side-effects such as capillary bleeding have been reported only in rats, with no apparent damage in larger models such as pigs and rabbits. Although local delivery is accomplished by applying ultrasound only to the target area, efficient delivery using conventional microbubbles has depended on the combined injection of both drugs and microbubbles directly into the renal artery. Conjugation of antibodies to the shell of microbubbles allows for the specific accumulation of microbubbles in the target tissue after intravenous injection. This exciting approach opens new possibilities for both drug delivery and diagnostic ultrasound imaging in the kidney.
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影响因子：
3.4
作者：
Dayton, PA;Chomas, JE;Ferrara, KW
通讯作者：
Ferrara, KW
影响因子：
37.8
作者：
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DOI：
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发表时间：
1997-06-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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