Involvement of trigeminal spinal nucleus in parasympathetic reflex vasodilatation in cat lower lip.
Involvement of trigeminal spinal nucleus in parasympathetic reflex vasodilatation in cat lower lip.
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三叉神经脊核参与猫下唇副交感反射血管舒张。
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
H. Izumi
中科院分区：
文献类型：
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作者：
K. Mizuta;S. Kuchiiwa;Takashi Saito;H. Mayanagi;K. Karita;H. Izumi
我们研究了三叉神经脊核（VSP）是否形成中枢机制的一部分，通过该机制，电刺激舌神经（LN）的中央切断端引起副交感神经反射血管扩张，在人工通气，颈部迷走神经切除猫深麻醉与α-氯醛糖和氨基甲酸乙酯的下唇。为此，我们在脑干内进行微量注射，以产生非选择性的、可逆的局部麻醉（利多卡因）或体细胞选择性的、不可逆的神经毒性损伤（红藻氨酸）。局部麻醉的VSP微量注射利多卡因（2%; 1微升/网站）可逆性和显着减少同侧LN引起的副交感神经反射血管舒张。单侧微量注射红藻氨酸（10毫米/网站; 1微升）到Vsp同侧刺激LN导致不可逆的减少反射血管舒张，但对刺激对侧LN引起的血管舒张没有影响。这种微量注射红藻氨酸到Vsp没有影响所引起的血管舒张电刺激同侧下唾液核。电刺激的VSP引起的血流量增加，在下唇的强度和频率依赖性的方式，无论全身动脉血压上升或下降。六烃季铵（1.0毫克/公斤iv）显着减少由电刺激LN或VSP的中央切断端引起的血管扩张反应，每个到一个相似的程度。六烃季铵后，两种血管舒张反应均显示时间依赖性恢复。这些结果表明，VSP是一个重要的延髓中继LN诱发的副交感神经反射血管扩张在猫下唇。
We examined whether the trigeminal spinal nucleus (Vsp) forms part of the central mechanism by which electrical stimulation of the central cut end of the lingual nerve (LN) evokes parasympathetic reflex vasodilatation in the lower lip in artificially ventilated, cervically vagosympathectomized cats deeply anesthetized with alpha-chloralose and urethane. For this purpose, we made microinjections within the brain stem to produce nonselective, reversible local anesthesia (lidocaine) or soma-selective, irreversible neurotoxic damage (kainic acid). Local anesthesia of Vsp by microinjection of lidocaine (2%; 1 microl/site) reversibly and significantly reduced the ipsilateral-LN-evoked parasympathetic reflex vasodilatation. Unilateral microinjection of kainic acid (10 mM/site; 1 microl) into Vsp ipsilateral to the stimulated LN led to an irreversible reduction in the reflex vasodilatation but had no effect on the vasodilatation elicited by stimulation of the contralateral LN. Such microinjection of kainic acid into Vsp had no effect on the vasodilatation evoked by electrical stimulation of the ipsilateral inferior salivatory nucleus. Electrical stimulation of Vsp elicited a blood flow increase in the lower lip in an intensity- and frequency-dependent manner, regardless of whether systemic arterial blood pressure rose or fell. Hexamethonium (1.0 mg/kg iv) significantly reduced the vasodilator responses elicited by electrical stimulation of the central cut end of LN or of Vsp, each to a similar degree. After hexamethonium, both vasodilator responses showed time-dependent recovery. These results strongly suggest that Vsp is an important bulbar relay for LN-evoked parasympathetic reflex vasodilatation in the cat lower lip.
影响因子：
2.5
作者：
Ren,K;Randich,A;Gebhart,GF
通讯作者：
Gebhart,GF