Clinical characteristics, treatment outcomes, and resource utilization in children and adults with eosinophilic gastroenteritis.
Clinical characteristics, treatment outcomes, and resource utilization in children and adults with eosinophilic gastroenteritis.
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DOI：
10.1016/j.dld.2014.11.009
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Dellon ES
中科院分区：
文献类型：
--
作者：
Reed C;Woosley JT;Dellon ES
嗜酸性粒细胞性胃肠炎是一种罕见疾病，在没有继发原因的情况下，胃肠道中发生嗜酸性粒细胞炎症。关于病因、发病机制或自然史知之甚少。描述嗜酸性粒细胞性胃肠炎的临床、内镜和组织病理学特征并总结治疗结果。回顾了2000年1月1日至2013年6月20日期间接受上消化道内镜活检的所有患者的病理报告。如果胃或十二指肠活检中嗜酸性粒细胞≥20/hpf，症状归因于胃肠道，并且没有已知的嗜酸性粒细胞增多的继发原因，则诊断为嗜酸性粒细胞性胃肠炎。描述性统计对诊断为嗜酸性粒细胞性胃肠炎的患者进行了特征分析，并对成人和儿童进行了双变量分析。有44名患者被诊断患有嗜酸粒细胞性胃肠道疾病。最常见的症状是呕吐（71%）和腹痛（62%）。在嗜酸性粒细胞性胃肠炎病例中，12 例（30%）有食管受累，11 例（28%）有结肠受累。为了治疗，36 人（80%）接受了皮质类固醇治疗。总体而言，27 名患者 (60%) 的症状得到缓解，23 名患者 (51%) 的内镜检查得到缓解。病例每年平均接受五次内窥镜手术。嗜酸性粒细胞性胃肠炎表现为非特异性胃肠道症状，几乎三分之一的病例伴有食管或结肠受累。它仍然难以治疗，内窥镜使用率很高。
Eosinophilic gastroenteritis is a rare condition where eosinophilic inflammation occurs in the gastrointestinal tract in the absence of secondary causes. Little is known regarding aetiology, pathogenesis, or natural history. To characterize the clinical, endoscopic, and histopathologic features of eosinophilic gastroenteritis and to summarize treatment outcomes. Pathologic reports of all patients who had undergone upper endoscopy with biopsy between January 1, 2000 and June 20, 2013 were reviewed. Eosinophilic gastroenteritis was diagnosed if there were ≥20 eosinophils/hpf on either gastric of duodenal biopsy, symptoms attributable to the gastrointestinal tract, and no known secondary cause of eosinophilia. Descriptive statistics characterized patients diagnosed with eosinophilic gastroenteritis and bivariate analysis compared adults and children. There were 44 patients diagnosed with eosinophilic gastrointestinal disease. The most common symptoms were vomiting (71%) and abdominal pain (62%). Of the eosinophilic gastroenteritis cases, 12 (30%) had esophageal involvement, and 11 (28%) had colonic involvement. For treatment, 36 (80%) received corticosteroids. Overall, 27 (60%) had symptom resolution and 23 (51%) had endoscopic resolution. Cases underwent a mean of five endoscopic procedures per year. Eosinophilic gastroenteritis presents with non-specific gastrointestinal symptoms and in almost one-third of cases has concomitant esophageal or colonic involvement. It remains difficult to treat, with high rates of endoscopic utilization.
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影响因子：
24.5
作者：
TALLEY, NJ;SHORTER, RG;ZINSMEISTER, AR
通讯作者：
ZINSMEISTER, AR
影响因子：
3.1
作者：
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影响因子：
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作者：
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DOI：
10.1097/mpg.0b013e3181eb5a9f
发表时间：
2011-03
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
--
作者：
Daneshjoo, Rahim;J Talley, Nicholas
通讯作者：
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