Coronary Artery Development: Progenitor Cells and Differentiation Pathways.
Coronary Artery Development: Progenitor Cells and Differentiation Pathways.
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DOI：
10.1146/annurev-physiol-022516-033953
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发表时间：
2017-02-10
影响因子：
18.2
通讯作者：
Red-Horse K
中科院分区：
文献类型：
--
作者：
Sharma B;Chang A;Red-Horse K
冠状动脉疾病（CAD）是世界范围内的头号死亡原因，并且涉及动脉壁内斑块的积累，其可以阻塞流向心脏的血流并引起心肌梗死。与CAD相关的高死亡率使得开发修复和替换患病动脉的医学干预措施成为心血管研究界的高度优先事项。动脉再生医学的进步可以受益于对胚胎发育过程中冠状动脉发育的详细了解，以及这些途径如何在疾病期间被重新点燃。最近的研究已经推进了我们对冠状动脉血管系统是如何构建的知识，并揭示了祖细胞部署的意想不到的功能，这些功能可能对器官发生有影响。在这里，我们强调这些最近的发现，并讨论他们如何设置阶段，询问在损伤和疾病的发展途径。
Coronary artery disease (CAD) is the number one cause of death worldwide and involves the accumulation of plaques within the artery wall that can occlude blood flow to the heart and cause myocardial infarction. The high mortality associated with CAD makes the development of medical interventions that repair and replace diseased arteries a high priority for the cardiovascular research community. Advancements in arterial regenerative medicine could benefit from a detailed understanding of coronary artery development during embryogenesis and of how these pathways might be reignited during disease. Recent research has advanced our knowledge on how the coronary vasculature is built and revealed unexpected features of progenitor cell deployment that may have implications for organogenesis in general. Here, we highlight these recent findings and discuss how they set the stage to interrogate developmental pathways during injury and disease.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
20.1
作者：
Compton, Leigh A.;Potash, Dru A.;Barnett, Joey V.
通讯作者：
Barnett, Joey V.
影响因子：
--
作者：
Bennett, HS
通讯作者：
Bennett, HS
影响因子：
4.6
作者：
Chen, Heidi I.;Sharma, Bikram;Red-Horse, Kristy
通讯作者：
Red-Horse, Kristy
影响因子：
5.7
作者：
Hauser, M
通讯作者：
Hauser, M