Prenatal stress suppresses the prefrontal and amygdaline EEG changes associated with a sexually-motivated state in male rats
Prenatal stress suppresses the prefrontal and amygdaline EEG changes associated with a sexually-motivated state in male rats
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产前应激抑制雄性大鼠与性动机状态相关的前额叶和杏仁核脑电图变化
DOI：
10.1016/j.physbeh.2017.10.003
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发表时间：
2017
影响因子：
2.9
通讯作者：
H. Bonilla
中科院分区：
文献类型：
--
作者：
M. Hernández;Enrique Hernández;M. A. Guevara;Mayra L. Almanza;Mayra Liliana Ramírez;M. Arteaga;H. Bonilla
内侧前额叶皮层（mPFC）和基底外侧杏仁核（BLA）参与了多种动机行为的调节，如性行为。当压力主要发生在生命周期的关键时期，如产前时期时，这两种结构都对压力敏感。本研究旨在评估产前应激对性动机过程中mPFC和BLA脑电图活动的影响。本实验记录了产前应激组（SG）和对照组（CG）雄性大鼠在清醒安静状态（无性动机）和清醒安静状态（有性动机）时mPFC和BLA的EEG。与对照组相比，SG组受试者出现交配反应的人数较少，性动机水平较低。有性动机的对照组被试在左侧mPFC和BLA的14-30 Hz频段的绝对功率（AP）高于无性动机的对照组。SG显示左侧BLA中4-7和8-13 Hz频段的AP较低。因此，产前压力抑制了与性动机状态相关的前额叶和杏仁核EEG变化。脑电图数据显示，压力会影响这两个大脑结构的功能，因此可能会干扰对性刺激的充分处理。这些发现有助于理解的大脑机制，产前压力对雄性大鼠的性刺激处理的影响。
The medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) participate in the modulation of several motivated behaviors, such as the sexual behavior. Both structures are sensitive to stress when it is experienced mainly in critical periods of the life-cycle, such as the prenatal period. This study evaluated the effects of prenatal stress on electroencephalographic activity (EEG) of the mPFC and BLA during sexual motivation. EEG was recorded in the mPFC and BLA of male rats assigned to either a prenatally-stressed group (SG, dam immobilized from days 14 to 21of pregnancy), or a control group (CG), during the following conditions: awake-quiet state without sexual motivation, and awake-quiet state with sexual motivation. Compared to CG, fewer SG subjects presented copulatory responses and their levels of sexual motivation were lower. The CG subjects with sexual motivation showed a higher absolute power (AP) of the 14–30 Hz band in the left mPFC and BLA than those without sexual motivation. The SG showed a lower AP of the 4–7 and 8–13 Hz bands in the left BLA. Thus, prenatal stress suppressed the prefrontal and amygdaline EEG changes associated with a sexually-motivated state. EEG data show that stress affects the functioning of these two brain structures and so could interfere with the adequate processing of sexual stimuli. These findings contribute to understanding the brain mechanisms that underlie the effect of prenatal stress on the processing of sexual stimuli in male rats.
影响因子：
2
作者：
Schoenbaum, G;Setlow, B;Gallagher, M
通讯作者：
Gallagher, M
在遭受围产期应激的成年雄性大鼠中，通过 H MRS 测量的脑 N-乙酰天冬氨酸浓度降低：初步观察和对神经发育障碍的假设影响。
影响因子：
4.8
作者：
Poland,RE;Cloak,C;Lutchmansingh,PJ;McCracken,JT;Chang,L;Ernst,T
通讯作者：
Ernst,T