Systematic Review of Literature Examining Bacterial Urinary Tract Infections in Diabetes.
Systematic Review of Literature Examining Bacterial Urinary Tract Infections in Diabetes.
复制标题
对糖尿病中细菌尿路感染的文献进行系统评价。
DOI：
10.1155/2022/3588297
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发表时间：
2022
影响因子：
4.3
通讯作者：
Kulkarni, Ritwij
中科院分区：
文献类型：
--
作者：
Paudel, Santosh;John, Preeti P.;Poorbaghi, Seyedeh Leila;Randis, Tara M.;Kulkarni, Ritwij
这篇系统性综述解决了中心研究问题，“从已发表的同行评议文献中了解到糖尿病对细菌性尿路感染（UTI）风险的影响吗？”我们检查了实验室研究的结果，研究人员成功地调整了糖尿病小鼠模型，以研究上行性UTI的病理生理学。这些研究已经确定了分子和细胞效应物，这些效应物形成针对糖尿病尿路感染的免疫防御。此外，我们从临床研究中获得的证据表明，除糖尿病外，女性性别、年龄增加和糖尿病相关的高血糖、糖尿和免疫功能障碍是进一步增加糖尿病患者UTI风险的重要风险因素。临床研究还表明，引起UTI的尿路致病菌属在糖尿病和非糖尿病个体之间基本相似，尽管糖尿病显著增加了耐药尿路致病菌引起UTI的风险。
This systematic review addresses the central research question, “what is known from the published, peer-reviewed literature about the impact of diabetes on the risk of bacterial urinary tract infections (UTI)?” We examine the results from laboratory studies where researchers have successfully adapted mouse models of diabetes to study the pathophysiology of ascending UTI. These studies have identified molecular and cellular effectors shaping immune defenses against infection of the diabetic urinary tract. In addition, we present evidence from clinical studies that in addition to diabetes, female gender, increased age, and diabetes-associated hyperglycemia, glycosuria, and immune impairment are important risk factors which further increase the risk of UTI in diabetic individuals. Clinical studies also show that the uropathogenic genera causing UTI are largely similar between diabetic and nondiabetic individuals, although diabetes significantly increases risk of UTI by drug-resistant uropathogenic bacteria.
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影响因子：
5.8
作者：
Bolinder, J.;Ljunggren, O.;Parikh, S.
通讯作者：
Parikh, S.
影响因子：
5.8
作者：
Bolinder, Jan;Ljunggren, Osten;Parikh, Shamik
通讯作者：
Parikh, Shamik
影响因子：
7.3
作者：
Barkai, Laszlo Jozsef;Sipter, Emese;Hosszufalusi, Nora
通讯作者：
Hosszufalusi, Nora
影响因子：
4.4
作者：
Diab, Randa A. Hadi;Fares, Mona;Hassan, Moustapha
通讯作者：
Hassan, Moustapha
影响因子：
3.4
作者：
Al-Rubeaan, Khalid A.;Moharram, Osama;Rafiullah, M. R. M.
通讯作者：
Rafiullah, M. R. M.